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| 標題: | Effects of perioperative magnesium on postoperative analgesia following thoracic surgery: a meta-analysis of randomised controlled trials |
| 作者: | Hung, Kuo-Chuan
Yang, Sheng-Hsiang
Liao, Shu-Wei
Yu, Chia-Hung
Liu, Mei-Yuan
Chen, Jen-Yin |
| 貢獻者: | Natl Sun Yat Sen Univ, Sch Med
Chi Mei Med Ctr, Dept Anesthesiol
Chi Mei Med Ctr, Dept Neurol
Chia Nan Univ Pharm & Sci
Southern Taiwan Univ Sci & Technol, Ctr Gen Educ
Chi Mei Med Ctr, Dept Nutr
Chung Hwa Univ Med Technol, Dept Food Nutr |
| 關鍵字: | Perioperative magnesium
thoracic surgery
postoperative pain |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:05:02 (UTC+8) |
| 出版者: | JLE |
| 摘要: | Objectives: To evaluate the analgesic effects of intravenous magnesium in patients undergoing thoracic surgery. Methods: Randomised clinical trials (RCTs) were systematically identified from MEDLINE, EMBASE, Google Scholar and the Cochrane Library from inception to May 1st, 2023. The primary outcome was the effect of intravenous magnesium on the severity of postoperative pain at 24 hours following surgery, while the secondary outcomes included association between intravenous magnesium and pain severity at other time points, morphine consumption, and haemodynamic changes. Results: Meta-analysis of seven RCTs published between 2007 and 2019, involving 549 adults, showed no correlation between magnesium and pain scores at 1-4 (standardized mean difference [SMD]=-0.06; p=0.58), 8-12 (SMD=-0.09; p=0.58), 24 (SMD=-0.16; p=0.42), and 48 (SMD=-0.27; p=0.09) hours post-surgery. Perioperative magnesium resulted in lower equivalent morphine consumption at 24 hours post-surgery (mean difference [MD]=-25.22 mg; p=0.04) and no effect at 48 hours (MD=-4.46 mg; p=0.19). Magnesium decreased heart rate (MD = -5.31 beats/min; p=0.0002) after tracheal intubation or after surgery, but had no effect on postoperative blood pressure (MD=-6.25 mmHg; p=0.11). There was a significantly higher concentration of magnesium in the magnesium group compared with that in the placebo group (MD = 0.91 mg/dL; p<0.00001). Conclusion: This meta-analysis provides evidence supporting perioperative magnesium as an analgesic adjuvant at 24 hours following thoracic surgery, but no opioid-sparing effect at 48 hours post |
| 關聯: | Magnesium Research, v.36, n.4, pp.54-68 |
| 顯示於類別: | [行政單位] 456
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