Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34870
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    题名: Incidence of second primary malignancies in women with different stages of breast cancer
    作者: Lin, Cheng-Yao
    Hsiao, Sheng-Yen
    Huang, Wen-Tsung
    Tsao, Chao-Jung
    Ho, Chung-Han
    Su, Shih-Bin
    Guo, How-Ran
    贡献者: Chi Mei Med Ctr, Dept Internal Med, Div Hematol Oncol
    Southern Taiwan Univ Sci & Technol, Dept Senior Welf & Serv
    Natl Cheng Kung Univ, Dept Environm & Occupat Hlth
    Chi Mei Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    Chi Mei Med Ctr, Dept Med Res
    Chi Mei Med Ctr, Dept Occupat Med
    Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med
    关键词: second primary malignancies
    breast cancer
    chemotherapy
    radiotherapy
    cancer stage
    日期: 2023
    上传时间: 2024-12-25 11:04:51 (UTC+8)
    出版者: FRONTIERS MEDIA SA
    摘要: Introduction: Breast cancer (BC) is the most common cancer in women worldwide. Because of the extended survival of patients with BC, the occurrence of second primary malignancies (SPMs) after BC is an important issue. Methods: We identified female patients with BC in the Breast Cancer Health Database of Taiwan, which includes four cancer registry datasets between 2002 and 2014 from Taiwan Cancer Registry. We compared the incidence of SPM between patients who received chemotherapy and/or radiotherapy with those who did not. Stratified analyses were performed according to the American Joint Committee on Cancer (AJCC) stage. The Cox regression model was used to identify the risk factors for SPM and evaluate their effects. Results: We enrolled 85,947 eligible patients with BC, and 2,656 (3.09%) patients developed SPM. The median duration of SPM was 2.70 (1.14-5.14) years. Radiotherapy was administered in 40,946 (47.64%) patients, and chemotherapy was administered in 52,120 (60.64%). The most common SPMs were digestive tract cancers (876, 31.89%). The risk factors for SPM included the AJCC stage, chemotherapy, radiotherapy, age, and underlying comorbidities. Neither chemotherapy nor radiotherapy was associated with an increased risk of SPM in any stage. In contrast, after adjusting for other risk factors, patients at stage III/IV who received both therapies had lower risks of SPM compared with those who did not (p = 0.047). Conclusion: The risk of SPM was different across BC stages. Neither chemotherapy nor radiotherapy was associated with an increased risk of SPM in women with BC.
    關聯: Frontiers in Oncology, v.12, Article 1047684
    显示于类别:[Dept. of Hospital and Health (including master's program)] Periodical Articles

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