Intrathecal dopamine and serotonin enhance motor and nociceptive blockades of lidocaine in rats

doi:10.1016/j.neulet.2023.137473

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Title:	Intrathecal dopamine and serotonin enhance motor and nociceptive blockades of lidocaine in rats
Authors:	Chiu, Chong-Chi Liu, Kuo-Sheng Wang, Jhi-Joung Chen, Yu-Wen Hung, Ching-Hsia
Contributors:	I Shou Univ, E Da Canc Hosp, Dept Neurol I Shou Univ, E Da Canc Hosp, Dept Med Educ & Res I Shou Univ, Coll Med, Sch Med Chia Nan Univ Pharm & Sci, Dept Pharm Tri Serv Gen Hosp, Dept Anesthesiol Natl Def Med Ctr Chi Mei Med Ctr, Dept Med Res China Med Univ, Coll Hlth Care, Dept Phys Therapy Natl Cheng Kung Univ, Coll Med, Dept Phys Therapy Natl Cheng Kung Univ, Inst Allied Hlth Sci, Coll Med Natl Cheng Kung Univ, Coll Med
Keywords:	Dopamine Serotonin Lidocaine Intrathecal injection Spinal block
Date:	2023
Issue Date:	2024-12-25 11:04:48 (UTC+8)
Publisher:	ELSEVIER IRELAND LTD
Abstract:	The study examined the effect of intrathecal injection of dopamine (serotonin) and/or lidocaine. Intrathecal injections of dopamine (serotonin or epinephrine), lidocaine, or their combination were carried out in male Sprague Dawley rats. Neurobehavioral examinations (motor and nociceptive reactions) were performed before and after spinal injection. Intrathecal serotonin (1.5 limol), dopamine (2.5 limol), epinephrine (1:40000), and lidocaine (0.75 limol) produced 29%, 33%, 29%, and 54% nociceptive blockade, whereas serotonin (1.5 limol), dopamine (2.5 limol), or epinephrine (1:40000) produced a longer duration of nociceptive blockade than lidocaine (0.75 limol) (P < 0.05). Serotonin (1.5 limol), dopamine (1.25 and 2.5 limol), or epinephrine (1:40000 and 1:80000) prolonged the duration and increased the potency of spinal motor and nociceptive blockades of lidocaine (50% effective dose, ED50) (P < 0.05). The motor and nociceptive blockades caused by lidocaine (ED50) plus dopamine (2.5 limol) or lidocaine (ED50) plus epinephrine (1:40000) were more outstanding than lidocaine (ED50) plus serotonin (0.75 limol) (P < 0.05). Our study provides evidence that intrathecal dopamine or serotonin produces spinal nociceptive blockade dose-dependently. Dopamine and serotonin are less potent than lidocaine in inducing spinal nociceptive blockade. When mixed with lidocaine solution, dopamine or serotonin improves spinal motor and nociceptive blockades. The motor and nociceptive blockade caused by lidocaine (ED50) plus dopamine (2.5 limol) is similar to that caused by lidocaine (ED50) plus epinephrine (1:40000).
Relation:	Neuroscience Letters, v.814, Article 137473
Appears in Collections:	[Offices] 456

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