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| 標題: | Zinc alleviates cadmium-induced reproductive toxicity via regulating ion homeostasis, metallothionein expression, and inhibiting mitochondria-mediated apoptosis in the freshwater crab Sinopotamon henanense |
| 作者: | Liu, Jing
Wang, Ermeng
Cheng, Ziru
Gao, Yuan
Chen, Chienmin
Jia, Ru
Luo, Zhi
Wang, Lan |
| 貢獻者: | Shanxi Univ, Sch Life Sci
Chia Nan Univ Pharm & Sci, Dept Environm Resource Management
Shanxi, Peoples R China |
| 關鍵字: | Sinopotamon henanense
Reproductive toxicity
Apoptosis
Metallothionein
Cadmium
Zinc |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:04:37 (UTC+8) |
| 出版者: | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 摘要: | Cadmium (Cd) is a carcinogenic environmental pollutant that harms male reproductive systems by lowering sperm quality, impairing spermatogenesis, and causing apoptosis. Although zinc (Zn) has been reported to alleviate Cd toxicity, the underlying mechanisms have not been fully elucidated. The aim of this work was to investigate the mitigating effects of Zn on Cd-induced male reproductive toxicity in the freshwater crab Sinopotamon henanense. Cd exposure not only resulted in its accumulation but also in Zn deficiency, decreased sperm survival rate, poor sperm quality, altered ultrastructure, and increased apoptosis in the testis of the crabs. Morever, Cd exposure increased the expression and distribution of metallothionein (MT) in the testis. However, Zn supplementation effectively mitigated the aforementioned effects of Cd, as demonstrated by preventing Cd accumulation, increasing Zn bioavailability, alleviating apoptosis, increasing mitochondrial membrane potential, decreasing reactive oxygen species (ROS) levels, and restoring MT distribution. Moreover, Zn also significantly reduced the expression of apoptosis-related (p53, Bax, CytC, Apaf-1, Caspase-9, Caspase-3), metal transporterrelated ZnT1, metal-responsive transcription factor 1 (MTF1), and the gene and protein expression of MT, while increasing the expression of ZIP1 and Bcl-2 in the testis of Cd-treated crabs. In conclusion, Zn alleviates Cdinduced reproductive toxicity via regulating ion homeostasis, MT expression, and inhibiting mitochondriamediated apoptosis in the testis of S. henanense. The information obtained in this study may serve as the foundation for further investigation into the development of mitigation strategies for adverse ecological and human health outcomes associated with Cd contamination or poisoning. |
| 關聯: | Ecotoxicology and Environmental Safety, v.262, Article 115188 |
| 顯示於類別: | [行政單位] 456
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