Lower product of magnesium x potassium is associated with higher mortality in chronic hemodialysis patients: a cohort study

doi:10.1038/s41598-023-49372-y

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Title:	Lower product of magnesium x potassium is associated with higher mortality in chronic hemodialysis patients: a cohort study
Authors:	Chen, Jui-Yi Jiang, Ming-Yan Huang, Yun-Ting Hwang, Jyh-Chang
Contributors:	Chi Mei Med Ctr, Dept Internal Med, Div Nephrol Chia Nan Univ Pharm & Sci, Dept Hlth & Nut Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Keywords:	Chronic Kidney-Disease Serum Magnesium Hypomagnesemia Hypokalemia Prevalence Kinetics
Date:	2023
Issue Date:	2024-12-25 11:04:10 (UTC+8)
Publisher:	NATURE PORTFOLIO
Abstract:	This study aimed to investigate the Mg x K product on the mortality risk of hemodialysis patients with concomitant hypokalemia and lower magnesium levels. This was a prospective observational study of patients in a HD center in southern Taiwan. A total of 444 HD patients were divided into 5 groups by the Mg x K product: group 1, bottom quintile, median Mg x K: 7.87, IQR: 7.03-8.12 (n = 89, age: 64 +/- 13 years old); group 2, median Mg x K: 9.37, IQR: 8.97-9.86 (n = 89, age:62 +/- 13 years old); group 3, median Mg x K: 10.95, IQR: 10.50-11.26 (n = 89, age:64 +/- 13 years old); group 4, median Mg x K: 12.30, IQR: 11.87-12.82 (n = 89, 61 +/- 12 years old); and group 5, top quintile, median Mg x K: 14.92, IQR:14.07-16.23 (n = 88, 62 +/- 11 years old). The patients were followed up for 2 years to determine the risk of all-cause mortality. Patients with a lower Mg x K product had more comorbidities, malnutrition-inflammation status, and a higher mortality risk. Using multivariable Cox regression analysis, a higher Mg x K [HR, 0.89; 95%CI (0.81-0.98)] was found to be an independent predictor of better survival. HD patients with a lower Mg x K product had more comorbidities, a marked malnutrition-inflammation status, and were associated with long-term mortality. A higher Mg x K value is a favorable survival factor.
Relation:	Scientific Reports, v.13, n.1, Article 22128
Appears in Collections:	[Offices] 456

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