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https://ir.cnu.edu.tw/handle/310902800/34823
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| 標題: | Water Extract from Brown Strain of Flammulina velutipes Alleviates Cisplatin-Induced Acute Kidney Injury by Attenuating Oxidative Stress, Inflammation, and Autophagy via PI3K/AKT Pathway Regulation |
| 作者: | Chou, Ya-Ni
Lee, Min-Min
Deng, Jeng-Shyan
Jiang, Wen-Ping
Lin, Jaung-Geng
Huang, Guan-Jhong |
| 貢獻者: | China Med Univ, Coll Chinese Med, Dept Chinese Pharmaceut Sci & Chinese Med Resource
Asia Univ, Dept Food Nutr & Hlth Biotechnol
Chia Nan Univ Pharm & Sci, Dept Pharm
China Med Univ, Coll Chinese Med, Sch Chinese Med
China Med Univ, Chinese Med Res Ctr |
| 關鍵字: | Flammulina velutipes
cisplatin
acute kidney injury
autophagy
PI3K/AKT pathway |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:04:05 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | One of the most popular edible mushrooms in the world, Flammulina velutipes, has been shown to possess pharmacological properties such as anti-inflammatory and antioxidant properties. However, the potential activity of the brown strain of F. velutipes, a hybrid between the white and yellow strains, has not been thoroughly investigated. Numerous studies have been conducted in recent years to determine whether natural products can aid in improving or treating kidney diseases. In this study, we focused on the renoprotective effects of the brown strain of F. velutipes on cisplatin-induced acute kidney injury (AKI) in mice. Mice were pretreated with water extract from the brown strain of F. velutipes (WFV) from day 1 to day 10, with a single-dose intraperitoneal injection of cisplatin on day 7 to induce AKI. Our results demonstrated that WFV administration resulted in a reduction in weight loss and the amelioration of renal function and renal histological changes in mice with cisplatin-induced AKI. WFV improved antioxidative stress and anti-inflammatory capacity by increasing antioxidant enzymes and decreasing inflammatory factors. The expression of related proteins was determined via Western blot analysis, which showed that WFV could improve the expression of apoptosis and autophagy. We used the PI3K inhibitor Wortmannin and found that WFV achieved a protective effect by modulating the PI3K/AKT pathway and the expression of autophagy. Overall, WFV as a natural substance could be used as a new therapeutic agent for AKI. |
| 關聯: | International Journal of Molecular Sciences, v.24, n.11, Article 9448 |
| 顯示於類別: | [行政單位] 456
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