The Clinical and Biological Effects of Receptor Expression-Enhancing Protein 6 in Tongue Squamous Cell Carcinoma

doi:10.3390/biomedicines11051270

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Title:	The Clinical and Biological Effects of Receptor Expression-Enhancing Protein 6 in Tongue Squamous Cell Carcinoma
Authors:	Tseng, Chung-Chih Hung, Chung-Ching Shu, Chih-Wen Lee, Cheng-Hsin Chen, Chun-Feng Kuo, Mei-Shu Kao, Yu-Ying Chen, Chun-Lin Ger, Luo-Ping Liu, Pei-Feng
Contributors:	Natl Sun Yat Sen Univ, Inst Med Sci & Technol Zuoying Branch Kaohsiung Armed Forces Gen Hosp, Dept Dent Zuoying Branch Kaohsiung Armed Forces Gen Hosp, Dept Otolaryngol Natl Sun Yat Sen Univ, Inst BioPharmaceut Sci Kaohsiung Med Univ, Coll Life Sci, Dept Biomed Sci & Environm Biol Kaohsiung Vet Gen Hosp, Dept Stomatol Chia Nan Univ, Dept Biotechnol Natl Sun Yat Sen Univ, Dept Biol Sci Kaohsiung Vet Gen Hosp, Dept Med Educ & Res Kaohsiung Med Univ Hosp, Dept Med Res Kaohsiung Med Univ, Ctr Canc Res Natl Sun Yat Sen Univ, Inst Biomed Sci
Keywords:	tongue squamous cell carcinoma receptor expression-enhancing protein 6 malignancy prognosis
Date:	2023
Issue Date:	2024-12-25 11:03:52 (UTC+8)
Publisher:	MDPI
Abstract:	There are currently no effective biomarkers for the diagnosis and treatment of tongue squamous cell carcinoma (TSCC), which causes a poor 5-year overall survival rate. Thus, it is crucial to identify more effective diagnostic/prognostic biomarkers and therapeutic targets for TSCC patients. The receptor expression-enhancing protein 6 (REEP6), a transmembrane endoplasmic reticulum resident protein, controls the expression or transport of a subset of proteins or receptors. Although it was reported that REEP6 plays a role in lung and colon cancers, its clinical impact and biological role in TSCC are still unknown. The present study aimed to identify a novel effective biomarker and therapeutic target for TSCC patients. Expression levels of REEP6 in specimens from TSCC patients were determined with immunohistochemistry. Gene knockdown was used to evaluate the effects of REEP6 in cancer malignancy (colony/tumorsphere formation, cell cycle regulation, migration, drug resistance and cancer stemness) of TSCC cells. The clinical impact of REEP6 expression and gene co-expression on prognosis were analyzed in oral cancer patients including TSCC patients from The Cancer Genome Atlas database. Tumor tissues had higher levels of REEP6 compared to normal tissues in TSCC patients. Higher REEP6 expression was related to shorter disease-free survival (DFS) in oral cancer patients with poorly differentiated tumor cells. REEP6-knocked-down TSCC cells showed diminished colony/tumorsphere formation, and they also caused G1 arrest and decreased migration, drug resistance and cancer stemness. A high co-expression of REEP6/epithelial-mesenchymal transition or cancer stemness markers also resulted in poor DFS in oral cancer patients. Thus, REEP6 is involved in the malignancy of TSCC and might serve as a potential diagnostic/prognostic biomarker and therapeutic target for TSCC patients.
Relation:	Biomedicines, v.11, n.5, Article 1270
Appears in Collections:	[Offices] 456

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