English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 18240/20438 (89%)
造訪人次 : 5416039      線上人數 : 932
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/34798


    標題: LAMC2 is a potential prognostic biomarker for cholangiocarcinoma
    作者: Ong, Khaa Hoo
    Hsieh, Yao-Yu
    Lai, Hong-Yue
    Sun, Ding-Ping
    Chen, Tzu-Ju
    Huang, Steven Kuan-Hua
    Tian, Yu-Feng
    Chou, Chia-Lin
    Shiue, Yow-Ling
    Wu, Hung-Chang
    Chan, Ti-Chun
    Tsai, Hsin-Hwa
    Li, Chien-Feng
    Kuo, Yu-Hsuan
    貢獻者: Chi Mei Med Ctr, Dept Surg, Div Gastroenterol & Gen Surg
    Chung Hwa Univ Med Technol, Dept Med Technol
    Natl Sun Yat Sen Univ, Inst Biomed Sci
    Taipei Med Univ, Shuang Ho Hosp, Div Hematol & Oncol
    Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med,Div Hematol & Oncol
    China Med Univ, Coll Med, Sch Med, Dept Pharmacol
    Chi Mei Med Ctr, Dept Clin Pathol, Div Urol
    Chi Mei Med Ctr, Dept Surg, Div Urol
    Chang Jung Christian Univ, Coll Hlth Sci, Dept Med Sci Ind
    Chi Mei Med Ctr, Dept Surg, Div Colon & Rectal Surg
    Natl Sun Yat Sen Univ, Inst Precis Med
    Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol
    Chia Nan Univ, Coll Pharm & Sci
    Chi Mei Med Ctr, Dept Med Res
    Natl Hlth Res Inst, Natl Inst Canc Res
    China Med Univ Hosp, Dept Lab Med
    Chi Mei Med Ctr, Trans Lab Precis Med
    關鍵字: laminin subunit gamma 2
    prognosis
    cholangiocarcinoma
    heparin binding
    日期: 2023
    上傳時間: 2024-12-25 11:03:40 (UTC+8)
    出版者: SPANDIDOS PUBL LTD
    摘要: Cholangiocarcinoma is a common malignancy with increasing incidence worldwide. Most patients are diagnosed at the advanced stage with poor survival rate. Laminin subunit gamma 2 (LAMC2) is a heparin binding-associated gene involved in tumorigenesis and has been implicated in the prognosis of various types of cancers. However, it is unclear whether expression of LAMC2 is associated with the clinical outcome of patients with cholangiocarcinoma. In the present study, the role and prognostic value of LAMC2 expression in patients with cholangiocarcinoma was investigated. Clinical information and pathological characteristics were analyzed and the association between LAMC2 expression and clinical characteristics, pathological findings and patient outcomes, including metastasis-free and disease-specific survival, were investigated. Data from 182 patients with cholangiocarcinoma were evaluated. High LAMC2 expression was associated with higher tumor stage (P<0.001), large duct type (P=0.024) and poor histological grade (P=0.002). Kaplan-Meier analysis showed high LAMC2 expression was associated with lower overall (P=0.003), disease-specific (P=0.0025), local recurrence-free (P<0.0001) and metastasis-free survival (P<0.0001). Moreover, multivariate analysis demonstrated that increased LAMC2 expression was a significant predictive risk factor for overall [hazard ratio (HR) 1.713; P=0.034], disease-specific (HR 2.011; P=0.039), local recurrence-free (HR 2.721; P<0.001) and metastasis-free survival (HR 3.117; P<0.001). Gene enrichment analysis using Gene Ontology showed that terms associated with LAMC2 upregulation were 'regulation of platelet-derived growth factor receptor-beta signaling pathway' and 'platelet-derived growth factor receptor-beta signaling pathway'. The present study indicated that LAMC2 was upregulated in cholangiocarcinoma tumor tissue and had an inverse association with overall, disease-specific, local recurrence-free and metastasis-free survival in patients with cholangiocarcinoma. These results suggested that LAMC2 may serve as a potential biomarker for cholangiocarcinoma.
    關聯: Oncology Letters, v.26, n.6, Article 533
    顯示於類別:[行政單位] 456

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML0檢視/開啟


    在CNU IR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋