Heat-killed Lacticaseibacillus paracasei GMNL-653 ameliorates human scalp health by regulating scalp microbiome

doi:10.1186/s12866-023-02870-5

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Title:	Heat-killed Lacticaseibacillus paracasei GMNL-653 ameliorates human scalp health by regulating scalp microbiome
Authors:	Tsai, Wen-Hua Fang, Yi-Ting Huang, Tsuei-Yin Chiang, Ying-Ju Lin, Ching-Gong Chang, Wen-Wei
Contributors:	GenMont Biotech Inc, Res & Dev Dept Chia Nan Univ Pharm & Sci, Dept Cosmet Sci, Bachelor Program Cosmeceut & Biotech Ind Chung Shan Med Univ, Dept Biomed Sci Chung Shan Med Univ Hosp, Dept Med Res
Keywords:	Heat-killed probiotics Lacticaseibacillus paracasei Shampoo Scalp health care Scalp microbiome
Date:	2023
Issue Date:	2024-12-24 18:00:18 (UTC+8)
Publisher:	BMC
Abstract:	BackgroundThe equilibrium of the scalp microbiome is important for maintaining healthy scalp conditions, including sebum secretion, dandruff, and hair growth. Many different strategies to improve scalp health have been reported; however, the effect of postbiotics, such as heat-killed probiotics, on scalp health remains unclear. We examined the beneficial effects of heat-killed probiotics consisting of Lacticaseibacillus paracasei, GMNL-653, on scalp health.ResultsHeat-killed GMNL-653 could co-aggregate with scalp commensal fungi, Malassezia furfur, in vitro, and the GMNL-653-derived lipoteichoic acid inhibited the biofilm formation of M. furfur on Hs68 fibroblast cells. The mRNA of hair follicle growth factors, including insulin-like growth factor-1 receptor (IGF-1R), vascular endothelial growth factor, IGF-1, and keratinocyte growth factor was up-regulated in skin-related human cell lines Hs68 and HaCaT after treatment with heat-killed GMNL-653. For clinical observations, we recruited 22 volunteer participants to use the shampoo containing the heat-killed GMNL-653 for 5 months and subsequently measured their scalp conditions, including sebum secretion, dandruff formation, and hair growth. We applied polymerase chain reaction (PCR) to detect the scalp microbiota of M. restricta, M. globosa, Cutibacterium acnes, and Staphylococcus epidermidis. A decrease in dandruff and oil secretion and an increase in hair growth in the human scalp were observed after the use of heat-killed GMNL-653-containing shampoo. The increased abundance of M. globosa and the decreased abundance of M. restricta and C. acnes were also observed. We further found that accumulated L. paracasei abundance was positively correlated with M. globosa abundance and negatively correlated with C. acnes abundance. S. epidermidis and C. acnes abundance was negatively correlated with M. globosa abundance and positively correlated with M. restricta. Meanwhile, M. globosa and M. restricta abundances were negatively associated with each other. C. acnes and S. epidermidis abundances were statistically positively correlated with sebum secretion and dandruff, respectively, in our shampoo clinical trial.ConclusionOur study provides a new strategy for human scalp health care using the heat-killed probiotics GMNL-653-containing shampoo. The mechanism may be correlated with the microbiota shift.
Relation:	Bmc Microbiology, v.23, n.1, Article 121
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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