Prognostic Significance of DNA Topoisomerase II Alpha (TOP2A) in Cholangiocarcinoma

doi:10.31083/j.fbl2804075

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Title:	Prognostic Significance of DNA Topoisomerase II Alpha (TOP2A) in Cholangiocarcinoma
Authors:	Ong, Khaa Hoo Lai, Hong-Yue Sun, Ding-Ping Chen, Tzu-Ju Huang, Steven Kuan-Hua Tian, Yu-Feng Chou, Chia-Lin Shiue, Yow-Ling Chan, Ti-Chun Li, Chien-Feng Kuo, Yu-Hsuan
Contributors:	Chi Mei Med Ctr, Dept Surg, Div Gastroenterol & Gen Surg Chung Hwa Univ Med Technol, Dept Med Technol Natl Sun Yat Sen Univ, Inst Biomed Sci China Med Univ, Sch Med, Dept Pharmacol Chi Mei Med Ctr, Dept Clin Pathol Chi Mei Med Ctr, Dept Surg, Div Urol Chang Jung Christian Univ, Coll Hlth Sci, Dept Med Sci Ind Chi Mei Med Ctr, Dept Surg, Div Colon & Rectal Surg Natl Sun Yat Sen Univ, Inst Precis Med Chi Mei Med Ctr, Dept Med Res Natl Hlth Res Inst, Natl Inst Canc Res Chi Mei Med Ctr, Trans Lab Precis Med Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol Chia Nan Univ, Coll Pharm & Sci
Keywords:	cholangiocarcinoma DNA topoisomerase (ATP-hydrolyzing activity) activity topoisomerase II alpha (TOP2A) prognostic biomarker
Date:	2023
Issue Date:	2024-12-24 18:00:04 (UTC+8)
Publisher:	IMR PRESS
Abstract:	Background: Cholangiocarcinoma (CCA) is a malignant tumor with an increasing incidence worldwide. Although radiation therapy has improved the therapeutic efficiency of CCA treatment, differential expression of genes among cholangiocarcinoma subtypes has been revealed through precise sequencing. However, no specific molecular therapeutic targets or biomarkers have been figured out for use in precision medicine, and the exact mechanism by which antitumorigenic effects occur is still unclear. Therefore, it is necessary to conduct further studies on the development and mechanisms associated with CCA. Methods: We examined the clinical data and pathological features of patients with cholangiocarcinomas. We investigated the associations between DNA Topoisomerase II Alpha (TOP2A) expression and patient outcomes, such as metastasis-free survival (MFS) and disease-specific survival (DSS), as well as clinical characteristics and pathological results. Results: TOP2A expression was shown to be upregulated in CCA tissue sections by immunohistochemistry staining and data mining. Moreover, we observed that the TOP2A expression correlated with clinical features, such as the primary tumor stage, histological variants, and patients with hepatitis. Furthermore, high expression of TOP2A was associated with worse survival outcomes in terms of the overall survival (p < 0.0001), disease-specific survival (p < 0.0001), and metastasis-free survival (p < 0.0001) compared with patients in the low TOP2A expression group. This indicates that a high level of TOP2A expression is related to an unfavorable prognosis. Conclusions: Our results show that TOP2A is highly expressed in CCA tissues, and its upregulation is correlated with the primary disease stage and poor prognosis significantly. Consequently, TOP2A is a prognostic biomarker and a novel therapeutic target for the treatment of CCA.
Relation:	Frontiers In Bioscience-Landmark, v.28, n.4, Article 75
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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