Low expression of ZSCAN4 predicts unfavorable outcome in urothelial carcinoma of upper urinary tract and urinary bladder

doi:10.1186/s12957-023-02948-4

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標題:	Low expression of ZSCAN4 predicts unfavorable outcome in urothelial carcinoma of upper urinary tract and urinary bladder
作者:	He, Hong-Lin Lai, Hong-Yue Chan, Ti-Chun Hsing, Chung-Hsi Huang, Steven K. Hsieh, Kun-Lin Chen, Tzu-Ju Li, Wan-Shan Kuo, Yu-Hsuan Shiue, Yow-Ling Li, Chien-Feng
貢獻者:	I Shou Univ, E DA Canc Hosp, Dept Pathol Chi Mei Med Ctr, Dept Med Res Natl Hlth Res Inst, Natl Inst Canc Res Chi Mei Med Ctr, Dept Anesthesiol Chi Mei Med Ctr, Dept Surg, Div Urol Chia Nan Univ Pharm & Sci, Dept Biotechnol Chi Mei Med Ctr, Dept Clin Pathol Chung Hwa Univ Med Technol, Dept Med Technol Chi Mei Med Ctr, Dept Pathol Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol Chia Nan Univ, Coll Pharm & Sci Natl Sun Yat Sen Univ, Inst Precis Med
關鍵字:	ZSCAN4 Urothelial carcinoma UC Prognosis Tumor suppressor
日期:	2023
上傳時間:	2024-12-24 18:00:03 (UTC+8)
出版者:	BMC
摘要:	BackgroundWith the advance in genome-wide analyses, genetic alternations have been found to play an important role in carcinogenesis and aggressiveness of UC. Through bioinformatic analysis of gene expression profiles of urinary bladder urothelial carcinoma (UBUC) from publicly available GEO dataset (GSE31684), Zinc finger and SCAN domain containing 4 (ZSCAN4) was identified as a significant downregulated gene in muscle-invasive bladder cancer when compared with non-muscle-invasive bladder cancer.MethodsThe expression of ZSCAN4 was evaluated by immunohistochemistry in 340 upper urinary tract urothelial carcinomas (UTUCs) and 295 UBUCs. The expression profiles of ZSCAN4 and potential signaling pathways were analyzed bioinformatically.ResultsIn UTUC, low expression of ZSCAN4 was significantly associated with advanced primary pT stage (P = 0.011), increased nodal metastasis (P = 0.002) and increased vascular invasion (P = 0.019). In UBUC, low expression of ZSCAN4 was significantly correlated with advanced primary pT stage (P < 0.001), increased nodal metastasis (P = 0.001), high histological grade (P = 0.003) and increased vascular invasion (P = 0.003). In survival analysis, low expression of ZSCAN4 acted as an independent negative prognostic factor for disease-specific survival and metastasis-free survival both in UTUC and UBUC. Gene ontology analysis showed that ZSCAN4 mRNA and its co-downregulated genes are associated with the mitotic cell cycle.ConclusionsLow expression of ZSCAN4 predicted worse outcome in urothelial carcinoma and might have potential regulatory role in cell mitosis.
關聯:	World Journal of Surgical Oncology, v.21, n.1, Article 62
显示于类别:	[生物科技系(所)] 期刊論文 [化妝品應用與管理系(所)] 期刊論文

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