雙酸性離子液體合成與其在催化點擊反應研究(II)

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標題:	雙酸性離子液體合成與其在催化點擊反應研究(II) Synthesis of Diacidic Ionic Liquids and Use as the Catalysts for Click Reaction Ii
作者:	何文岳
貢獻者:	化粧品應用與管理系(含化粧品科技碩士班)
關鍵字:	點擊化學疊氮-炔基環加成反應離子液體 Click chemistry Azide-alkyne cycloaddition reaction Ionic liquid
日期:	2022
上傳時間:	2024-05-11 11:36:20 (UTC+8)
摘要:	離子液體為近十年來相當受到注目的綠色溶劑，本計畫以實驗室所開發具有布忍司特-路易士雙酸性的離子液體為催化劑，進行點擊反應研究，探討其在催化疊氮-炔基環加成反應的影響，有助於在材料科學、組合化學、化學生物學及藥物化學等應用領域之發展。 Click reaction has the characteristics of high yield, good regiospecificity and easy product purification. It is widely used in vary fields such as materials science, combinatorial chemistry, chemical biology and medicinal chemistry, and copper(I) catalyzed azide-alkyne cycloaddition reaction (CuAAC) is a classical reaction thereof. However, CuAAC reaction has drawbacks such as necessary to add special additives, use highly toxic organic solvents to speed the reaction, or the catalyst is not easy to recover after the reaction. This research uses the Brønsted-Lewis diacidic ionic liquids 3a-3l which have developed in our previous work as the catalyst for the azide-alkyne cycloaddition reaction. It reveals the yield of 1-benzyl-4-phenyl-1H-1,2,3- triazole over 3f reached 98% in 3 hr at room temperature. Catalytic 3f is stable in water and air, and the highest catalytic activity could still be maintained after 4 cycles.
關聯:	計畫編號：MOST111-2221-E041-001 計畫年度：111 計畫起訖：2022-08~2023-07
顯示於類別:	[化妝品應用與管理系(所)] 科技部計畫

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