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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34707


    標題: Real-world effectiveness of direct-acting antivirals in people living with human immunodeficiency virus and hepatitis C virus genotype 6 infections
    作者: Sun, Hsin-Yun
    Cheng, Chien-Yu
    Lin, Chi-Ying
    Yang, Chia-Jui
    Lee, Nan-Yao
    Liou, Bo-Huang
    Tang, Hung-Jen
    Liu, Yuang-Meng
    Lee, Chun-Yuan
    Chen, Tun-Chieh
    Huang, Yi-Chia
    Lee, Yuan-Ti
    Tsai, Ming-Jui
    Lu, Po-Liang
    Tsai, Hung-Chin
    Wang, Ning-Chi
    Hung, Tung-Che
    Cheng, Shu-Hsing
    Hung, Chien-Ching
    貢獻者: National Taiwan University
    National Taiwan University Hospital
    National Taiwan University
    National Yang Ming Chiao Tung University
    National Taiwan University
    National Taiwan University Hospital
    Far Eastern Memorial Hospital
    National Yang Ming Chiao Tung University
    National Cheng Kung University
    National Cheng Kung University Hospital
    Mackay Memorial Hospital
    Chi Mei Hospital
    Chia Nan University of Pharmacy & Science
    Changhua Christian Hospital
    Kaohsiung Medical University
    Kaohsiung Medical University Hospital
    Kaohsiung Medical University
    Kaohsiung Medical University
    National Taiwan University
    National Taiwan University Hospital
    Chung Shan Medical University
    Chung Shan Medical University Hospital
    Chung Shan Medical University
    Kaohsiung Medical University
    Kaohsiung Medical University Hospital
    Kaohsiung Medical University
    Kaohsiung Veterans General Hospital
    National Defense Medical Center
    Tri-Service General Hospital
    National Taiwan University
    China Medical University Taiwan
    China Medical University Hospital - Taiwan
    China Medical University Taiwan
    關鍵字: taiwan consensus statement
    therapy
    management
    日期: 2022
    上傳時間: 2023-12-11 14:06:18 (UTC+8)
    出版者: BAISHIDENG PUBLISHING GROUP INC
    摘要: BACKGROUND Hepatitis C virus (HCV) genotype 6 (HCV-6) infection is prevalent predominantly in Southeast Asia, and the data on the virologic response of HCV-6 to direct-acting antivirals (DAAs) are sparse in people living with human immunodeficiency virus (HIV) (PLWH). AIM To assess the virologic response of HCV-6 to DAAs in PLWH. METHODS From September 2016 to July 2019, PLWH coinfected with HCV-6 initiating DAAs were included. Laboratory investigations were performed at baseline, the end of treatment, and 12 wk off-therapy. RESULTS Of the 349 PLWH included (mean age 48.9 years, 82.5% men), 80.5% comprised people who inject drugs, 18.1% men who have sex with men, and 1.4% heterosexuals. Coexistent hepatitis B virus infection was present in 12.3% of the included PLWH, liver cirrhosis 10.9%, hepatocellular carcinoma 0.9%, and previous HCV treatment experience 10.9%. The mean baseline plasma HCV RNA was 6.2 log 10 IU/mL. Treatment with glecaprevir/pibrentasvir was initiated in 51.9%, sofosbuvir/ledipasvir 41.5%, sofosbuvir/velpatasvir 6.3%, and sofosbuvir/daclatasvir 0.3%. At DAA initiation, antiretroviral therapy containing tenofovir alafenamide was given in 26.4%, tenofovir disoproxil fumarate 34.4%, non-tenofovir alafenamide/tenofovir disoproxil fumarate 39.3%, non- nucleoside reverse-transcriptase inhibitors 30.4%, protease inhibitors 4.0%, and integrase strand transfer inhibitors 66.8%; 94.8% of the included patients had CD4 counts = 200 cells/mm3 and 96.0% had plasma HIV RNA < 50 copies/mL. Overall, 96.8% achieved undetectable plasma HCV RNA (< 30 IU/mL) at end of treatment; and 92.3% achieved sustained virologic response 12 wk off-therapy in the intention-to-treat analysis (93.5% in patients receiving sofosbuvir-based DAAs and 91.2% in those receiving glecaprevir/pibrentasvir). CONCLUSION Similar to the observation made in HIV-negative patients, sustained virologic response 12 wk offtherapy with DAAs is high in PLWH coinfected with HCV-6.
    關聯: WORLD JOURNAL OF GASTROENTEROLOGY, v.28, n.CB2, pp.CC2, pp.-,
    Appears in Collections:[行政單位] 123

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