Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34699
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    標題: Short- and long-term recurrence of early-stage invasive ductal carcinoma in middle-aged and old women with different treatments
    作者: Kao, Yuan
    Wu, Ying-Jhen
    Hsu, Chien-Chin
    Lin, Hung-Jung
    Wang, Jhi-Joung
    Tian, Yu-Feng
    Weng, Shih-Feng
    Huang, Chien-Cheng
    貢獻者: Chi Mei Hospital
    Chang Jung Christian University
    Kaohsiung Medical University
    Kaohsiung Municipal Siao-Gang Hospital
    Taipei Medical University
    Chi Mei Hospital
    National Defense Medical Center
    Chi Mei Hospital
    Chia Nan University of Pharmacy & Science
    Kaohsiung Medical University
    Kaohsiung Medical University Hospital
    Kaohsiung Medical University
    Kaohsiung Medical University
    Kaohsiung Medical University
    Kaohsiung Medical University
    關鍵字: breast-cancer
    日期: 2022
    上傳時間: 2023-12-11 14:05:48 (UTC+8)
    出版者: NATURE PORTFOLIO
    摘要: Most new cases and the highest mortality rates of breast cancer occur among middle-aged and old women. The recurrence rate of early-stage invasive ductal carcinoma (IDC) among women aged >= 50 years and receiving different treatments remains unclear. Therefore, this study was conducted to determine these rates. We used Surveillance, Epidemiology, and End Results (SEER) data for this nationwide population-based cohort study. All women aged >= 50 years and diagnosed with early-stage IDC between 2000 and 2015 were identified and divided into three treatment groups, namely, breast conservation therapy (BCT), mastectomy alone (MAS), and mastectomy with radiation therapy (MAS + RT). The recurrence rates of IDC among these groups were then compared. The BCT group had a lower short-term recurrence risk than the MAS and MAS + RT groups (hazard ratio [HR]: 1.00 vs. 2.90 [95% CI 1.36-2.66] vs. 2.07 [95% CI 0.97-4.44]); however, the BCT group also had a higher long-term recurrence risk than MAS and MAS + RT groups (HR 1.00 vs. 0.30 [95% CI 0.26-0.35] vs. 0.43 [95% CI 0.30-0.63]). The high long-term recurrence rate of the BCT group was especially prominent at the 10- and 15-year follow-ups. The results provide valuable evidence of the most reliable treatment strategy for this population. Further studies including more variables and validation in other countries are warranted to confirm our findings.
    關聯: SCIENTIFIC REPORTS, v.12, n.CB2, pp.CC2, pp.-857,
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