Efficacy of high-flow nasal oxygenation against peri- and post-procedural hypoxemia in patients with obesity: a meta-analysis of randomized controlled trials

doi:10.1038/s41598-022-10396-5

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標題:	Efficacy of high-flow nasal oxygenation against peri- and post-procedural hypoxemia in patients with obesity: a meta-analysis of randomized controlled trials
作者:	Hung, Kuo-Chuan Ko, Ching-Chung Chang, Po-Chih Wang, Kuei-Fen Teng, I-Chia Lin, Chien-Hung Huang, Ping-Wen Sun, Cheuk-Kwan
貢獻者:	Chi Mei Hospital Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy & Science Department of Health and Nutrition, Chia Nan University of Pharmacy & Science Kaohsiung Medical University Kaohsiung Medical University Hospital Show Chwan Memorial Hospital E-Da Hospital I Shou University
關鍵字:	preoxygenation atelectasis intubation cannula anesthesia management therapy
日期:	2022
上傳時間:	2023-12-11 14:05:39 (UTC+8)
出版者:	NATURE PORTFOLIO
摘要:	This meta-analysis aimed at investigating the efficacy of high-flow nasal oxygenation (HFNO) against hypoxemia in patients with obesity compared with conventional oxygenation therapy and non-invasive ventilation. Databases were searched from inception to August 2021. Studies involving peri- or post-procedural use of HFNO were included. The primary outcome was risk of hypoxemia, while the secondary outcomes included status of oxygenation and carbon dioxide elimination. Ten randomized controlled trials (RCTs) were included. We found that HFNO prolonged the safe apnea time at induction compared to control group [mean difference (MD) = 73.88 s, p = 0.0004; 2 RCTs] with no difference in risk of peri-procedural hypoxemia [relative risk (RR) = 0.91, p = 0.64; 4 RCTs], minimum SpO2 (MD = 0.09%, p = 0.95; 4 RCTs), PaO2 (MD = - 8.13 mmHg, p = 0.86; 3 RCTs), PaCO2 (MD = - 6.71%, p = 0.2; 2 RCTs), EtCO2 (MD = - 0.28 mmHg, p = 0.8; 4 RCTs) between the two groups. HFNO also did not improve postprocedural PaO2/FiO2 ratio (MD = 41.76, p = 0.58; 2 RCTs) and PaCO2 (MD = - 2.68 mmHg, p = 0.07; 2 RCTs). This meta-analysis demonstrated that the use of HFNO may be associated with a longer safe apnea time without beneficial impact on the risk of hypoxemia, oxygenation, and CO2 elimination in patients with obesity. The limited number of trials warranted further large-scale studies to support our findings.
關聯:	Scientific Reports, v.12, n.1, Article 6448
顯示於類別:	[醫務管理系(所)] 期刊論文 [保健營養系(所) ] 期刊論文

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