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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34696

    標題: Efficacy of high-flow nasal oxygenation against peri- and post-procedural hypoxemia in patients with obesity: a meta-analysis of randomized controlled trials
    作者: Hung, Kuo-Chuan
    Ko, Ching-Chung
    Chang, Po-Chih
    Wang, Kuei-Fen
    Teng, I-Chia
    Lin, Chien-Hung
    Huang, Ping-Wen
    Sun, Cheuk-Kwan
    貢獻者: Chi Mei Hospital
    Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy & Science
    Department of Health and Nutrition, Chia Nan University of Pharmacy & Science
    Kaohsiung Medical University
    Kaohsiung Medical University Hospital
    Show Chwan Memorial Hospital
    E-Da Hospital
    I Shou University
    關鍵字: preoxygenation
    日期: 2022
    上傳時間: 2023-12-11 14:05:39 (UTC+8)
    摘要: This meta-analysis aimed at investigating the efficacy of high-flow nasal oxygenation (HFNO) against hypoxemia in patients with obesity compared with conventional oxygenation therapy and non-invasive ventilation. Databases were searched from inception to August 2021. Studies involving peri- or post-procedural use of HFNO were included. The primary outcome was risk of hypoxemia, while the secondary outcomes included status of oxygenation and carbon dioxide elimination. Ten randomized controlled trials (RCTs) were included. We found that HFNO prolonged the safe apnea time at induction compared to control group [mean difference (MD) = 73.88 s, p = 0.0004; 2 RCTs] with no difference in risk of peri-procedural hypoxemia [relative risk (RR) = 0.91, p = 0.64; 4 RCTs], minimum SpO2 (MD = 0.09%, p = 0.95; 4 RCTs), PaO2 (MD = - 8.13 mmHg, p = 0.86; 3 RCTs), PaCO2 (MD = - 6.71%, p = 0.2; 2 RCTs), EtCO2 (MD = - 0.28 mmHg, p = 0.8; 4 RCTs) between the two groups. HFNO also did not improve postprocedural PaO2/FiO2 ratio (MD = 41.76, p = 0.58; 2 RCTs) and PaCO2 (MD = - 2.68 mmHg, p = 0.07; 2 RCTs). This meta-analysis demonstrated that the use of HFNO may be associated with a longer safe apnea time without beneficial impact on the risk of hypoxemia, oxygenation, and CO2 elimination in patients with obesity. The limited number of trials warranted further large-scale studies to support our findings.
    關聯: Scientific Reports, v.12, n.1, Article 6448
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