A Novel Soy Isoflavone Derivative, 3′-Hydroxyglycitin, with Potent Antioxidant and Anti-α-Glucosidase Activity

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Title:	A Novel Soy Isoflavone Derivative, 3′-Hydroxyglycitin, with Potent Antioxidant and Anti-α-Glucosidase Activity
Authors:	Wu, Jiumn-Yih Wang, Tzi-Yuan Ding, Hsiou-Yu Lee, Chuan-Che Chang, Te-Sheng
Contributors:	Academia Sinica - Taiwan Department of Cosmetic Science, Chia Nan University of Pharmacy & Science National University Tainan
Keywords:	b16 melanoma-cells ortho-hydroxydaidzein flavonoids
Date:	2022
Issue Date:	2023-12-11 14:04:59 (UTC+8)
Publisher:	MDPI
Abstract:	This study demonstrated the enzymatic hydroxylation of glycitin to 3'-hydroxyglycitin, confirming the structure by mass and nucleic magnetic resonance spectral analyses. The bioactivity assays further revealed that the new compound possessed over 100-fold higher 1,1-diphenyl-2-picrylhydrazine free-radical scavenging activity than the original glycitin, although its half-time of stability was 22.3 min. Furthermore, the original glycitin lacked anti-alpha-glucosidase activity, whereas the low-toxic 3'-hydroxyglycitin displayed a 10-fold higher anti-alpha-glucosidase activity than acarbose, a standard clinical antidiabetic drug. The inhibition mode of 3'-hydroxyglycitin was noncompetitive, with a K-i value of 0.34 mM. These findings highlight the potential use of the new soy isoflavone 3'-hydroxyglycitin in biotechnology industries in the future.
Relation:	PLANTS-BASEL, v.11, n.17, 2202
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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