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| 標題: | Overexpression of Dehydrogenase/Reductase 9 Predicts Poor Response to Concurrent Chemoradiotherapy and Poor Prognosis in Rectal Cancer Patients |
| 作者: | Chen, Tzu-Ju
Hsu, Bei-Hao
Lee, Sung-Wei
Yang, Ching-Chieh
Tian, Yu-Feng
Kuo, Yu-Hsuan
Li, Wan-Shan
Tsai, Hsin-Hwa
Wu, Li-Ching
Yeh, Cheng-Fa
Chou, Chia-Lin
Lai, Hong-Yue |
| 貢獻者: | Chi Mei Hospital
Chung Hua University
Chung Shan Medical University
Chung Shan Medical University Hospital
Department of Pharmacy, Chia Nan University of Pharmacy & Science
Chia Nan University of Pharmacy & Science
National Sun Yat Sen University
Chi Mei Hospital
China Medical University Taiwan
China Medical University Hospital - Taiwan
Chia Nan University of Pharmacy & Science |
| 關鍵字: | keratan sulfate
expression
glycosaminoglycan
differentiation
muc2 |
| 日期: | 2022 |
| 上傳時間: | 2023-12-11 14:04:41 (UTC+8) |
| 出版者: | FRONTIERS MEDIA SA |
| 摘要: | Objective: To reduce the risk of locoregional recurrence, the addition of neoadjuvant concurrent chemoradiotherapy (CCRT) is recommended before surgical management for rectal cancer patients. However, despite identical tumor histology, individual patient response to neoadjuvant CCRT varies greatly. Accordingly, a comprehensive molecular characterization that is used to predict CCRT efficacy is instantly needed.Methods: Pearson's chi-squared test was utilized to correlate dehydrogenase/reductase 9 (DHRS9) expression with clinicopathological features. Survival curves were created applying the Kaplan-Meier method, and the log-rank test was conducted to compare prognostic utility between high and low DHRS9 expression groups. Multivariate Cox proportional hazards regression analysis was applied to identify independent prognostic biomarkers based on variables with prognostic utility at the univariate level.Results: Utilizing a public transcriptome dataset, we identified that the DHRS9 gene is the most considerably upregulated gene related to epithelial cell differentiation (GO: 0030855) among rectal cancer patients with CCRT resistance. Employing immunohistochemical staining, we also demonstrated that high DHRS9 immunoexpression is considerably associated with an aggressive clinical course and CCRT resistance in our rectal cancer cohort. Among all variables with prognostic utility at the univariate level, only high DHRS9 immunoexpression was independently unfavorably prognostic of all three endpoints (all p <= 0.048) in the multivariate analysis. In addition, applying bioinformatic analysis, we also linked DHRS9 with unrevealed functions, such as keratan sulfate and mucin synthesis which may be implicated in CCRT resistance.Conclusion: Altogether, DHRS9 expression may serve as a helpful predictive and prognostic biomarker and assist decision-making for rectal cancer patients who underwent neoadjuvant CCRT. |
| 關聯: | PATHOLOGY & ONCOLOGY RESEARCH, v.28, Article 1610537 |
| 顯示於類別: | [藥學系(所)] 期刊論文
[化妝品應用與管理系(所)] 期刊論文
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