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| 標題: | Upregulated Ubiquitin D is a Favorable Prognostic Indicator for Rectal Cancer Patients Undergoing Preoperative Concurrent Chemoradiotherapy |
| 作者: | Chou, Chia-Lin
Chen, Tzu-Ju
Li, Wan-Shan
Lee, Sung-Wei
Yang, Ching-Chieh
Tian, Yu-Feng
Lin, Cheng-Yi
He, Hong -Lin
Wu, Hung-Chang
Shiue, Yow-Ling
Li, Chien-Feng
Kuo, Yu-Hsuan |
| 貢獻者: | Chung Hua University
Chi Mei Hospital
Chi Mei Hospital
Chi Mei Hospital
National Sun Yat Sen University
Chi Mei Hospital
Chi Mei Hospital
Chia Nan University of Pharmacy & Science
Chi Mei Hospital
I Shou University
Chi Mei Hospital
National Sun Yat Sen University
Chi Mei Hospital
National Health Research Institutes - Taiwan |
| 關鍵字: | hepatocellular-carcinoma
increased expression
protein fat10
gene
progression
metastasis |
| 日期: | 2022 |
| 上傳時間: | 2023-12-11 14:04:15 (UTC+8) |
| 出版者: | DOVE MEDICAL PRESS LTD |
| 摘要: | Purpose: For locally advanced rectal cancer, neoadjuvant concurrent chemoradiotherapy (CCRT) allows tumor downstaging and makes curative radical proctectomy possible. However, we lack a genetic biomarker to predict cancer prognosis or treatment response. We investigated the association between ubiquitin D (UBD) expression and clinical outcomes in rectal cancer patients receiving CCRT. Patients and Methods: We analyzed the genes associated with the protein modification process (GO:0036211) and identified the UBD gene as the most relevant among the top 7 differentially expressed genes associated with CCRT resistance. We collected tissue specimens from 172 rectal cancer patients who had received CCRT followed by a curative proctectomy. We examine the relationship between UBD expression and patient characteristics, pathological findings, and patient survival, such as metastasis-free survival (MeFS) and disease-specific survival. Results: Upregulated UBD expression was associated with lower pre-CCRT tumor T stage (P = 0.009), lower post-CCRT tumor T stage (P < 0.001), lower post-CCRT nodal stage (P < 0.001), less vascular invasion (P = 0.015), and better tumor regression (P < 0.001). Using univariate analysis, we found that high UBD expression was correlated with better disease-free survival (DFS) (P < 0.0001), local recurrence-free survival (LRFS) (P < 0.0001) and MeFS (P < 0.0001). Moreover, multivariate analysis demonstrated that high UBD expression was associated with superior DFS (P < 0.001), LRFS (P = 0.01), and MeFS (P = 0.004). Conclusion: UBD upregulation was linked to better clinical prognosis, favorable pathological features, and good treatment response in rectal cancer patients undergoing CCRT. These results suggest UBD is a biomarker for rectal cancer. |
| 關聯: | ONCOTARGETS AND THERAPY, v.15, n.CB2, pp.CC2, pp.-, |
| 顯示於類別: | [藥學系(所)] 期刊論文
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