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    標題: Upregulated Ubiquitin D is a Favorable Prognostic Indicator for Rectal Cancer Patients Undergoing Preoperative Concurrent Chemoradiotherapy
    作者: Chou, Chia-Lin
    Chen, Tzu-Ju
    Li, Wan-Shan
    Lee, Sung-Wei
    Yang, Ching-Chieh
    Tian, Yu-Feng
    Lin, Cheng-Yi
    He, Hong -Lin
    Wu, Hung-Chang
    Shiue, Yow-Ling
    Li, Chien-Feng
    Kuo, Yu-Hsuan
    貢獻者: Chung Hua University
    Chi Mei Hospital
    Chi Mei Hospital
    Chi Mei Hospital
    National Sun Yat Sen University
    Chi Mei Hospital
    Chi Mei Hospital
    Chia Nan University of Pharmacy & Science
    Chi Mei Hospital
    I Shou University
    Chi Mei Hospital
    National Sun Yat Sen University
    Chi Mei Hospital
    National Health Research Institutes - Taiwan
    關鍵字: hepatocellular-carcinoma
    increased expression
    protein fat10
    gene
    progression
    metastasis
    日期: 2022
    上傳時間: 2023-12-11 14:04:15 (UTC+8)
    出版者: DOVE MEDICAL PRESS LTD
    摘要: Purpose: For locally advanced rectal cancer, neoadjuvant concurrent chemoradiotherapy (CCRT) allows tumor downstaging and makes curative radical proctectomy possible. However, we lack a genetic biomarker to predict cancer prognosis or treatment response. We investigated the association between ubiquitin D (UBD) expression and clinical outcomes in rectal cancer patients receiving CCRT. Patients and Methods: We analyzed the genes associated with the protein modification process (GO:0036211) and identified the UBD gene as the most relevant among the top 7 differentially expressed genes associated with CCRT resistance. We collected tissue specimens from 172 rectal cancer patients who had received CCRT followed by a curative proctectomy. We examine the relationship between UBD expression and patient characteristics, pathological findings, and patient survival, such as metastasis-free survival (MeFS) and disease-specific survival. Results: Upregulated UBD expression was associated with lower pre-CCRT tumor T stage (P = 0.009), lower post-CCRT tumor T stage (P < 0.001), lower post-CCRT nodal stage (P < 0.001), less vascular invasion (P = 0.015), and better tumor regression (P < 0.001). Using univariate analysis, we found that high UBD expression was correlated with better disease-free survival (DFS) (P < 0.0001), local recurrence-free survival (LRFS) (P < 0.0001) and MeFS (P < 0.0001). Moreover, multivariate analysis demonstrated that high UBD expression was associated with superior DFS (P < 0.001), LRFS (P = 0.01), and MeFS (P = 0.004). Conclusion: UBD upregulation was linked to better clinical prognosis, favorable pathological features, and good treatment response in rectal cancer patients undergoing CCRT. These results suggest UBD is a biomarker for rectal cancer.
    關聯: ONCOTARGETS AND THERAPY, v.15, n.CB2, pp.CC2, pp.-,
    顯示於類別:[藥學系(所)] 期刊論文

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