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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34671

    標題: High MT2A Expression Predicts Worse Prognosis in Patients with Urothelial Carcinoma
    作者: Li, Wei-Ming
    Ke, Hung-Lung
    Kuo, Yu-Hsuan
    Lai, Hong-Yue
    Chan, Ti-Chun
    Hsing, Chung-Hsi
    Hsieh, Kun-Lin
    Li, Wan-Shan
    Chen, Tzu-Ju
    Wei, Yu-Ching
    Wu, Wen-Jeng
    Huang, Steven K.
    Li, Chien-Feng
    貢獻者: Kaohsiung Medical University
    Kaohsiung Medical University Hospital
    Kaohsiung Municipal Ta-Tung Hospital
    Chi Mei Hospital
    Chia Nan University of Pharmacy & Science
    National Health Research Institutes - Taiwan
    Chung Hua University
    Kaohsiung Municipal Ta-Tung Hospital
    Chang Jung Christian University
    關鍵字: upper urinary-tract
    metallothionein 2a
    日期: 2022
    上傳時間: 2023-12-11 14:04:12 (UTC+8)
    出版者: KARGER
    摘要: Introduction: Dysregulation of metal ion homeostasis is associated with urothelial carcinogenesis. From a published urinary bladder urothelial carcinoma (UBUC) transcriptome, we identified metallothionein 2A (MT2A) as the most significantly upregulated gene implicated in cancer progression among metal ion binding-related genes. Therefore, we analyzed the association between MT2A expression and clinical significance in our well-characterized cohort of patients with upper tract urothelial carcinoma (UTUC) and UBUC. Methods: We retrospectively reviewed the clinicopathological characteristics of 295 and 340 patients with UBUC and UTUC, respectively. MT2A expression was assessed using real-time reverse transcriptase-polymerase chain reaction and immunohistochemistry. We further correlated MT2A expression with clinicopathological factors, disease-specific survival (DSS) and metastasis-free survival (MFS) using the Pearson's chi(2) test, Kaplan-Meier analysis, and multivariate Cox proportional hazards model. Results: High MT2A expression was significantly associated with aggressive pathological features including high tumor stage, lymph node metastasis, high tumor grade, vascular invasion, and perineural invasion. In the Kaplan-Meier analysis, high MT2A expression was significantly correlated with poor DSS (p < 0.0001) and MFS (p < 0.0001); in the multivariate analysis, it was an independent predictor of CSS (p < 0.001) and MFS (p = 0.001). Gene coexpression analysis demonstrated that MT2A overexpression promotes UC progression through complement activation. Conclusion: High MT2A expression correlated with aggressive UC features and was an independent predictor of cancer metastasis and patient survival, suggesting its role in risk stratification and decision-making in patients with UTUC and UBUC.
    關聯: ONCOLOGY, v.100, n.9, pp.485–497
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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