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| 標題: | High MT2A Expression Predicts Worse Prognosis in Patients with Urothelial Carcinoma |
| 作者: | Li, Wei-Ming
Ke, Hung-Lung
Kuo, Yu-Hsuan
Lai, Hong-Yue
Chan, Ti-Chun
Hsing, Chung-Hsi
Hsieh, Kun-Lin
Li, Wan-Shan
Chen, Tzu-Ju
Wei, Yu-Ching
Wu, Wen-Jeng
Huang, Steven K.
Li, Chien-Feng |
| 貢獻者: | Kaohsiung Medical University
Kaohsiung Medical University Hospital
Kaohsiung Municipal Ta-Tung Hospital
Chi Mei Hospital
Chia Nan University of Pharmacy & Science
National Health Research Institutes - Taiwan
Chung Hua University
Kaohsiung Municipal Ta-Tung Hospital
Chang Jung Christian University |
| 關鍵字: | upper urinary-tract
metallothionein 2a
bladder-cancer
complement
cells
indicator
risk |
| 日期: | 2022 |
| 上傳時間: | 2023-12-11 14:04:12 (UTC+8) |
| 出版者: | KARGER |
| 摘要: | Introduction: Dysregulation of metal ion homeostasis is associated with urothelial carcinogenesis. From a published urinary bladder urothelial carcinoma (UBUC) transcriptome, we identified metallothionein 2A (MT2A) as the most significantly upregulated gene implicated in cancer progression among metal ion binding-related genes. Therefore, we analyzed the association between MT2A expression and clinical significance in our well-characterized cohort of patients with upper tract urothelial carcinoma (UTUC) and UBUC. Methods: We retrospectively reviewed the clinicopathological characteristics of 295 and 340 patients with UBUC and UTUC, respectively. MT2A expression was assessed using real-time reverse transcriptase-polymerase chain reaction and immunohistochemistry. We further correlated MT2A expression with clinicopathological factors, disease-specific survival (DSS) and metastasis-free survival (MFS) using the Pearson's chi(2) test, Kaplan-Meier analysis, and multivariate Cox proportional hazards model. Results: High MT2A expression was significantly associated with aggressive pathological features including high tumor stage, lymph node metastasis, high tumor grade, vascular invasion, and perineural invasion. In the Kaplan-Meier analysis, high MT2A expression was significantly correlated with poor DSS (p < 0.0001) and MFS (p < 0.0001); in the multivariate analysis, it was an independent predictor of CSS (p < 0.001) and MFS (p = 0.001). Gene coexpression analysis demonstrated that MT2A overexpression promotes UC progression through complement activation. Conclusion: High MT2A expression correlated with aggressive UC features and was an independent predictor of cancer metastasis and patient survival, suggesting its role in risk stratification and decision-making in patients with UTUC and UBUC. |
| 關聯: | ONCOLOGY, v.100, n.9, pp.485–497 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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