Suboptimal Plasma Vitamin C Is Associated with Lower Bone Mineral Density in Young and Early Middle-Aged Men: A Retrospective Cross-Sectional Study

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標題:	Suboptimal Plasma Vitamin C Is Associated with Lower Bone Mineral Density in Young and Early Middle-Aged Men: A Retrospective Cross-Sectional Study
作者:	Lan, Kuo-Mao Wang, Li-Kai Lin, Yao-Tsung Hung, Kuo-Chuan Wu, Li-Ching Ho, Chung-Han Chang, Chia-Yu Chen, Jen-Yin
貢獻者:	Chi Mei Hospital Chi Mei Hospital Chia Nan University of Pharmacy & Science Chi Mei Hospital National Sun Yat Sen University Chi Mei Hospital Chi Mei Hospital Southern Taiwan University of Science & Technology
關鍵字:	body-mass index 25-hydroxyvitamin d postmenopausal women serum concentrations adult patients ascorbic-acid d deficiency risk-factors osteoporosis fractures
日期:	2022
上傳時間:	2023-12-11 14:03:52 (UTC+8)
出版者:	MDPI
摘要:	Background: This study was conducted to evaluate associations between bone mineral density (BMD) and four selected circulating nutrients, particularly vitamin C, among adults aged 20-49 years. Methods: In this retrospective cross-sectional study, the lumbar spine BMD of 866 men and 589 women were measured by dual-energy X-ray absorptiometry and divided into tertiles, respectively. Logistic regressions were used to identify the predictors of low BMD by comparing subjects with the highest BMD to those with the lowest. Results: Multivariate logistic regressions identified suboptimal plasma vitamin C (adjusted odds ratio (AOR) 1.64, 95% confidence interval (CI) 1.16, 2.31), suboptimal serum vitamin B12 (AOR 2.05, 95% CI 1.02, 4.12), and low BMI (BMI < 23) (AOR 1.68, 95% CI 1.12, 2.53) as independent predictors for low BMD in men. In women, low BMI was the only independent predictor for low BMD. Plasma vitamin C, categorized as suboptimal (<= 8.8 mg/L) and sufficient (>8.8 mg/L), was positively significantly correlated with the lumbar spine BMD in men, but there was no association in women. Conclusions: Plasma vitamin C, categorized as suboptimal and sufficient, was positively associated with the lumbar spine BMD in young and early middle-aged men. A well-designed cohort study is needed to confirm the findings.
關聯:	NUTRIENTS, v.14, n.CB2, pp.CC2, pp.-3124,
显示于类别:	[行政單位] 123

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