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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34660


    標題: A Taiwan nationwide population-based study of socio-demographic factors and comorbid conditions associated with non-arteritic anterior ischemic optic neuropathy
    作者: Jan, Ren-Long
    Ho, Chung-Han
    Wang, Jhi-Joung
    Chang, Yuh-Shin
    貢獻者: Chang Jung Christian University
    Chi Mei Hospital
    Chia Nan University of Pharmacy & Science, Department of Hospital and Health Care Administration
    Chi Mei Hospital
    Chi Mei Hospital
    關鍵字: nerve head
    risk
    pathogenesis
    日期: 2023
    上傳時間: 2023-12-11 14:03:34 (UTC+8)
    出版者: KARGER
    摘要: Aims: To investigate the socio-demographic factors and systemic conditions associated with non-arteritic anterior ischaemic optic neuropathy (NAION).Methods: This was a nationwide population-based retrospective case-controlled study that recruited 9,261 NAION patients selected from the Taiwan National Health Insurance Research Database. The control group consisted of 9,261 age-, sex-, and index date-matched non-NAION patients recruited from the Taiwan Longitudinal Health Insurance Database, 2000. NAION was designated in the database by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) as code 377.41: ischaemic optic neuropathy without ICD-9-CM code 446.5: giant cell arteritis. Associated socio-demographic factors and systemic medical conditions were analysed using the McNemar's test, and continuous variables were analysed using the paired t-test. The odds ratio (OR) and adjusted OR of developing NAION were compared using univariate logistic regression and multivariable logistic regression analyses, respectively.Results: Patients with systemic conditions such as diabetes mellitus, hypertension, hyperlipidaemia, chronic kidney disease, and hypotension were more likely to develop NAION than controls (adjusted OR=1.81, 95% CI=1.67-1.97, p<0.0001; adjusted OR=1.46, 95% CI=1.36-1.57, p<0.0001; adjusted OR=1.44, 95% CI=1.33-1.57, p<0.0001; adjusted OR=3.26, 95% CI=2.65-4.01, p<0.0001; adjusted OR=2.32, 95% CI=1.31-4.10, p=0.0039, respectively). Patients residing in Eastern Taiwan or in a metropolitan city had higher odds of developing NAION. Patients with a monthly income between NT$ 30,000 and NT$ 90,000 and those whose jobs were others also had significantly higher ORs of developing NAION. Conclusions: NAION is strongly associated with diabetes mellitus, hypertension, hyperlipidaemia, chronic kidney disease, and hypotension.
    關聯: NEUROEPIDEMIOLOGY, v.57, n.1, pp.35–42
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