Alpha-Mangostin Reduces Pericellular Fibronectin on Suspended Tumor Cells and Therapeutically, but Not Prophylactically, Suppresses Distant Metastasis

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Title:	Alpha-Mangostin Reduces Pericellular Fibronectin on Suspended Tumor Cells and Therapeutically, but Not Prophylactically, Suppresses Distant Metastasis
Authors:	Huang, Li-Tzu Kuo, Chin-Ho Tseng, Lin Li, Yi-Syuan Cheng, Li-Hsin Cheng, Chin-Yun Sheu, Shane-Rong Chang, Wen-Tsan Chen, Chien-Chin Cheng, Hung-Chi
Contributors:	National Cheng Kung University National Cheng Kung University Department of Cosmetic Science, Chia Nan University of Pharmacy & Science National Cheng Kung University
Keywords:	kinase-c-epsilon breast-cancer cells oxidative stress protein rat adhesion xanthones anoikis surface growth
Date:	2022
Issue Date:	2023-12-11 14:02:12 (UTC+8)
Publisher:	MDPI
Abstract:	Major cancer deaths can be ascribed to distant metastasis to which the assembly of pericellular fibronectin (periFN) on suspended tumor cells (STCs) in the bloodstream that facilitate endothelial attachment can lead. Even though mangosteen pericarps (MP) extracts and the major component alpha-mangostin (alpha-MG) exhibit potent cancer chemopreventive properties, whether they can prophylactically and therapeutically be used as dietary nutraceuticals to prevent distant metastasis by suppressing periFN assembly on STCs within the circulation remains obscure. Immunofluorescence staining, MTT assays, flow cytometric assays, immunoblotting, and experimental metastasis mouse models were used to detect the effects of MP extracts or alpha-MG on periFN on STCs, tumor cell proliferation and apoptosis, the AKT activity, and tumor lung metastasis. The periFN assembly on STCs was significantly diminished upon treatments of STCs with either alpha-MG or MP extracts in a dose-dependent manner without inhibiting cell proliferation and viability due to increased AKT activity. Pretreatment of STCs with alpha-MG appeared to suppress tumor lung metastasis and prolong mouse survival rates. Oral gavage with MP extracts could therapeutically, but not prophylactically, prevent lung metastasis of STCs. We concluded that MP extracts or the major component alpha-MG may therapeutically serve as a potent anti-metastatic nutraceutical.
Relation:	LIFE-BASEL, v.12, n.9, 1375
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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