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| 標題: | Risk of non-typhoidal Salmonella vascular infections is increased with degree of atherosclerosis and inflammation: A multicenter study in southern Taiwan |
| 作者: | Chen, Ying-Wen
Tang, Hung-Jen
Tsai, Yi-Shan
Lee, Nan-Yao
Hung, Yuan-Pin
Huang, Chien-Fang
Lee, Ching-Chi
Li, Chia-Wen
Li, Ming-Chi
Syue, Ling-Shan
Su, Shu-Li
Hsu, Shu-Hao
Ko, Wen-Chien
Chen, Po-Lin |
| 貢獻者: | National Cheng Kung University
National Cheng Kung University Hospital
Chi Mei Hospital
Chia Nan University of Pharmacy & Science
National Cheng Kung University
National Cheng Kung University Hospital
National Cheng Kung University
National Cheng Kung University
National Cheng Kung University Hospital
National Health Research Institutes - Taiwan
National Cheng Kung University
National Cheng Kung University Hospital
National Cheng Kung University
National Cheng Kung University Hospital
National Cheng Kung University |
| 關鍵字: | predicting vascular infections
matrix metalloproteinases
nontyphoid salmonella
endovascular infection
cardiovascular risk
disease
calcification
association
bacteremia
aneurysms |
| 日期: | 2022 |
| 上傳時間: | 2023-12-11 14:01:31 (UTC+8) |
| 出版者: | ELSEVIER TAIWAN |
| 摘要: | Background: Atherosclerosis and vascular inflammatory response have been considered as risk factors for non-typhoidal Salmonella (NTS) vascular infection. The study aims to assess the risk of vascular infection by measuring atherosclerosis severity, NTS vascular infection (NTSVI) score, and serum levels of inflammatory markers in people with NTS bacteremia. Methods: A prospective observational study was conducted in two medical centers and two regional hospitals. Adults aged >= 50 years with NTS bacteremia who underwent computed tomography (CT) scan for revealing vascular infections were enrolled. The degree of atherosclerosis was scaled by a calcium score determined by a CT scan. Serum concentrations of inflammatory biomarkers were determined in the patients enrolled in a medical center. Results: Fourteen (20.3%) of 69 patients with NTS bacteremia had vascular infections. Calcium scores over the thoracic (12,540 vs. 3,261, P = 0.0005) and abdominal (9755 vs. 3,461, P = 0.0006) aorta of those with vascular infections were higher than those without vascular infection. All vascular infections were present in the high-risk group (NTSVI score > 1), yielding a sensitivity of 100% and specificity of 30.9%. Among 17 low-risk patients (NTSVI score < 1), none had vascular infections, resulting in a negative predictive value of 100%. Higher plasma concentrations of IL-10 were detected in the cases of vascular infection than those in the control group (23.6 vs. 1.06 pg/mL, P = 0.001). Conclusion: Atherosclerosis of the aorta which is associated with a positive NTSVI score can predict the occurrence of vascular infections and serum IL-10 could be a biomarker for vascular infection in patients with NTS bacteremia. Copyright (C) 2021, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. |
| 關聯: | JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, v.55, n.CB2, pp.CC2, pp.-290, |
| 顯示於類別: | [行政單位] 123
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