Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34623
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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34623


    Title: The study of distribution of ingested terbinafine on skin with ambient ionization tandem mass spectrometry
    Authors: Cho, Yi-Tzu
    Su, Hung
    Wu, Ching-Ying
    Jeng, Jingyueh
    Lee, Chi-Wei
    Wu, Deng-Chyang
    Huang, Tiao-Lai
    Shiea, Jentaie
    Contributors: National Sun Yat Sen University
    Kaohsiung Medical University
    Department of Medicinal Chemistry, Chia Nan University of Pharmacy & Science
    National Sun Yat Sen University
    Kaohsiung Medical University Hospital
    Chang Gung Memorial Hospital
    Keywords: of-care identification
    dermis-epidermis
    stratum-corneum
    volatile compounds
    oral fluid
    sweat
    hair
    sebum
    drugs
    pharmacokinetics
    Date: 2022
    Issue Date: 2023-12-11 14:01:14 (UTC+8)
    Publisher: DIGITAL COMMONS BEPRESS
    Abstract: We aim to develop an efficient and non-invasive strategy for monitoring of drugs and their metabolites via human skin. Probe sampling was combined with thermal desorption-electrospray ionization tandem mass spectrometry (TD-ESI/MS/MS) to characterize trace terbinafine, which was secreted on patient's skin after ingesting terbinafine tablets. The terbinafine ion signals were directly detected in the samples collected from different skin regions and the signals were monitored for 8 weeks. The detection and location of terbinafine via the skin suggest that the methods are useful in rapidly and noninvasively collecting the molecular information of the ingested drug on skin for pharmacokinetic studies.
    Relation: Journal of food and drug analysis, v.30, n.2
    Appears in Collections:[Dept. of Food & Drug Industry and Inspective Technology] Periodical Articles

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