The study of distribution of ingested terbinafine on skin with ambient ionization tandem mass spectrometry

CNU IR > Pharmacy and Science > Dept. of Food & Drug Industry and Inspective Technology > Periodical Articles > Item 310902800/34623

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题名:	The study of distribution of ingested terbinafine on skin with ambient ionization tandem mass spectrometry
作者:	Cho, Yi-Tzu Su, Hung Wu, Ching-Ying Jeng, Jingyueh Lee, Chi-Wei Wu, Deng-Chyang Huang, Tiao-Lai Shiea, Jentaie
贡献者:	National Sun Yat Sen University Kaohsiung Medical University Department of Medicinal Chemistry, Chia Nan University of Pharmacy & Science National Sun Yat Sen University Kaohsiung Medical University Hospital Chang Gung Memorial Hospital
关键词:	of-care identification dermis-epidermis stratum-corneum volatile compounds oral fluid sweat hair sebum drugs pharmacokinetics
日期:	2022
上传时间:	2023-12-11 14:01:14 (UTC+8)
出版者:	DIGITAL COMMONS BEPRESS
摘要:	We aim to develop an efficient and non-invasive strategy for monitoring of drugs and their metabolites via human skin. Probe sampling was combined with thermal desorption-electrospray ionization tandem mass spectrometry (TD-ESI/MS/MS) to characterize trace terbinafine, which was secreted on patient's skin after ingesting terbinafine tablets. The terbinafine ion signals were directly detected in the samples collected from different skin regions and the signals were monitored for 8 weeks. The detection and location of terbinafine via the skin suggest that the methods are useful in rapidly and noninvasively collecting the molecular information of the ingested drug on skin for pharmacokinetic studies.
關聯:	Journal of food and drug analysis, v.30, n.2
显示于类别:	[Dept. of Food & Drug Industry and Inspective Technology] Periodical Articles

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