Novel application of a Co-Fermented postbiotics of TYCA06/AP-32/CP-9/collagen in the improvement of acne vulgaris-A randomized clinical study of efficacy evaluation

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Title:	Novel application of a Co-Fermented postbiotics of TYCA06/AP-32/CP-9/collagen in the improvement of acne vulgaris-A randomized clinical study of efficacy evaluation
Authors:	Ho, Hsieh-Hsun Chen, Ching-Wei Yi, Tsai-Hsuan Huang, Yu-Fen Kuo, Yi-Wei Lin, Jia-Hung Chen, Jui-Fen Tsai, Shin-Yu Chan, Leong-Perng Liang, Chia-Hua
Contributors:	Kaohsiung Medical University Kaohsiung Municipal Ta-Tung Hospital Kaohsiung Medical University Kaohsiung Medical University Hospital Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy & Science
Keywords:	propionibacterium-acnes gut microbiota erythromycin clindamycin bacteria
Date:	2022
Issue Date:	2023-12-11 14:01:06 (UTC+8)
Publisher:	WILEY
Abstract:	Background Acne vulgaris is a chronic inflammatory skin disease. If skin lesions are not treated well in time, they can leave a permanent impact on the appearance and a negative influence on personal confidence. The common therapy for acne symptom includes antibiotics, benzoyl peroxide, and azeleic acid. However, those medications have side effects, and the long-term use should be cautious. Therefore, it is necessary to develop a safe and effective material, which is more suitable for daily use. Objective Collagen was selected to co-ferment with three probiotic strains TYCA06/AP-32/CP-9 (TAC) due to its excellent feature on wound healing. The fermented material was added into cosmetic gel and applied on subjects' acne lesions. The antimicrobial activity against Propionibacterium acnes and anti-inflammation effect around lesion area were investigated in a 4-week clinical study. Material and Methods An anti-P. acnes assay, a keratinocytes HaCaT cell-based wound healing assay, and a cytokine assay on thymic stromal lymphopoietin (TSLP) and interleukin (IL)-33 were used to evaluate the function of the fermented material in vitro. The TAC/Collagen formula was further incorporated into a cosmetic gel, and the human clinical trial was carried out by applying this gel on 20 volunteers' face with acne vulgaris. The moisture score, sebum content, inflammation, porphyrins numbers, and brown spot number of whole face were observed and recorded. Results The postbiotics of the TAC/Collagen displayed a good growth inhibition against P. acnes and reduced TSLP and IL-33 inflammation in vitro. This TAC/Collagen formula enhanced the wound healing in HaCaT cell culture. The result of the clinical trial showed the TAC/Collagen gel improved the moisture score and inflammation index of the skin in vivo. In addition, this TAC/Collagen gel also improved the wound healing of acne symptom in volunteers with acne vulgaris. Moreover, this TAC/Collagen gel reduced the number of the porphyrins and brown spots on facial skin. Conclusion These postbiotics of TAC/Collagen have beneficial effects on skin health and are able to ameliorate the redness, inflammation, and acne symptom in acne vulgaris patients.
Relation:	JOURNAL OF COSMETIC DERMATOLOGY, v.21, n.11, pp.6249-6260
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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