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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34613

    標題: GRK3 as a Prognosis Biomarker in Gastric Cancer
    作者: Fang, Chia-Lang
    Tian, Yu-Feng
    Lin, Shiau-Shiuan
    Hung, Shih-Ting
    Hseu, You-Cheng
    Chang, Chun-Chao
    Chou, Chia-Lin
    Chen, Li-Chin
    Wang, Wen-Ching
    Lin, Kai-Yuan
    Sun, Ding-Ping
    貢獻者: Taipei Medical University
    Taipei Medical University Hospital
    Chi Mei Hospital
    China Medical University Taiwan
    Asia University Taiwan
    China Medical University Taiwan
    Department of Biotechnology, Chia Nan University of Pharmacy & Science
    Department of Food Science and Technology, Chia Nan University of Pharmacy & Science
    關鍵字: coupled receptor kinases
    日期: 2022
    上傳時間: 2023-12-11 14:00:46 (UTC+8)
    摘要: Background: Globally, gastric cancer is ranked 4th and 3rd in terms of incidence and mortality rate among all cancer types. This study aimed to examine the relationship between G protein-coupled receptor kinase 3 (GRK3) and gastric cancer prognosis and investigate the role of GRK3 in gastric cancer carcinogenesis. Methods: GRK3 level in gastric tissues and cells were determined using immunohistochemistry and immunoblotting. Kaplan-Meier analysis with the log-rank test was employed to evaluate the relationship between GRK3 expression and gastric cancer prognosis. RNAi technology was applied to examine the effects of GRK3 inhibition on gastric cancer proliferation and spread. Results: GRK3 overexpression was correlated significantly with lymphatic metastasis (P = 0.0011), distant metastasis (P < 0.0001), TNM stage (P = 0.0035), and vascular invasion (P = 0.0025). Kaplan-Meier survival analysis showed that the disease-free survival and overall survival of patients with high GRK3 expression were significantly shorter than those of patients with low GRK3 expression. Multivariate Cox regression analysis also showed that the overexpression of GRK3 was an independent prognostic biomarker of gastric cancer (P = 0.029). In cultured gastric cancer cells, GRK3 knockdown inhibited cell proliferation, migration, and invasion. Further analysis revealed that more GRK3-knockdown cells were in G0/G1 phase and few cells were in S phase, thereby inhibiting cell proliferation. Conclusions: GRK3 overexpression can be a candidate biomarker for gastric cancer prognosis. GRK3 is also a potential therapeutic target for gastric cancer.
    關聯: JOURNAL OF CANCER, v.13, n.4, pp. 1299-1306
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