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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34607

    標題: The Association of Erythropoietin and Age-Related Macular Degeneration in Hemodialysis Patients: A Nationwide Population-Based Cohort Study
    作者: Huang, Evelyn-Jou-Chen
    Sung, Fung-Chang
    Hung, Peir-Haur
    Muo, Chih-Hsin
    Wu, Meei-Maan
    Yeh, Chih-Ching
    貢獻者: Taipei Medical University
    Taipei Medical University Hospital
    Taipei Medical University
    China Medical University Taiwan
    China Medical University Taiwan
    China Medical University Hospital - Taiwan
    Asia University Taiwan
    Department of Applied Life Science and Health, Chia Nan University of Pharmacy & Science
    China Medical University Taiwan
    Taipei Medical University
    Taipei Medical University
    Taipei Medical University
    China Medical University Taiwan
    Taipei Medical University
    Taipei Municipal WanFang Hospital
    關鍵字: chronic kidney-disease
    stage renal-disease
    eye disease
    日期: 2022
    上傳時間: 2023-12-11 14:00:29 (UTC+8)
    出版者: MDPI
    摘要: This population-based retrospective cohort study investigated the effectiveness of erythropoietin (EPO) treatment in reducing the risk of age-related macular degeneration (AMD) in hemodialysis patients, using the National Health Insurance Research Data of Taiwan. From the database, we identified 147,318 end-stage renal disease (ESRD) patients on hemodialysis who had been diagnosed in 2000-2014 to establish the propensity-score-matched EPO user cohort and non-EPO user cohort with equal sample size of 15,992. By the end of 2016, the cumulative incidence of AMD in EPO users was about 3.29% lower than that in non-EPO users (Kaplan-Meier survival p < 0.0001). The risk of AMD was 43% lower in EPO users than in non-EPO users, with an adjusted hazard ratio (aHR) of 0.57 (95% confidence interval (CI) = 0.51-0.64) estimated in the multivariate Cox model. A significant negative dose-response relationship was identified between the EPO dosage and the risk of AMD (p < 0.0001). Another beneficial effect of EPO treatment was a reduced risk of both exudative AMD (aHR = 0.48, 95% CI = 0.40-0.61) and non-exudative AMD (aHR = 0.61, 95% CI = 0.53-0.69), also in similar dose-response relationships (p < 0.0001). Our findings suggest that EPO treatment for hemodialysis patients could reduce AMD risk in a dose-response relationship.
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