Schizophyllum commune Reduces Expression of the SARS-CoV-2 Receptors ACE2 and TMPRSS2

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Title:	Schizophyllum commune Reduces Expression of the SARS-CoV-2 Receptors ACE2 and TMPRSS2
Authors:	Sun, Te-Kai Huang, Wen-Chin Sun, Yu-Wen Deng, Jeng-Shyan Chien, Liang-Hsuan Chou, Ya-Ni Jiang, Wen-Ping Lin, Jaung-Geng Huang, Guan-Jhong
Contributors:	China Medical University Taiwan China Medical University Taiwan China Medical University Taiwan Asia University Taiwan Department of Pharmacy, Chia Nan University of Pharmacy & Science China Medical University Taiwan
Keywords:	schizophyllum commune adenosine sars-cov-2 ace2 tmprss2
Date:	2022
Issue Date:	2023-12-11 14:00:23 (UTC+8)
Publisher:	MDPI
Abstract:	The current global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of COVID-19 has infected hundreds of millions of people, killed millions, and continues to pose a threat. It has become one of the largest epidemics in human history, causing enormous damage to people's lives and economies in the whole world. However, there are still many uncertainties and continued attention to the impact of SARS-CoV-2 on human health. The entry of SARS-CoV-2 into host cells is facilitated by the binding of the spike protein on the virus surface to the cell surface receptor angiotensin-converting enzyme 2 (ACE2). Furthermore, transmembrane protease serine 2 (TMPRSS2) is a host surface protease that cleaves and proteolytically activates its S protein, which is necessary for viral infection. Thus, SARS-CoV-2 uses the ACE2 receptor for cell entry and initiates the S protein using the protease TMPRSS2. Schizophyllum commune (SC) is one of the most widely distributed fungi, often found on the rotten wood of trees that has been found to have various health benefits, including anticancer, antimicrobial activity, antiparasitic, and immunomodulatory function. In this article, SC significantly diminished the expression ACE2 and TMPRSS2 protein in vitro and in vivo without cell damage. In addition, adenosine from SC was also proven in this experiment to reduce the ACE2 and TMPRSS2 expression. Thus, our findings suggest that SC and adenosine exhibit potential for the repression of SARS-CoV-2 infection via the ACE2 and TMPRSS2 axis.
Relation:	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, n.23, pp.14766
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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