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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34598

    標題: Switching to coformulated bictegravir, emtricitabine, and tenofovir alafenamide maintained viral suppression in adults with historical virological failures and K65N/R mutation
    作者: Tsai, Mao -Song
    Sun, Hsin-Yun
    Chen, Cheng-Pin
    Lee, Chen -Hsiang
    Lee, Chun -Yuan
    Liu, Chun -Eng
    Tang, Hung -Jen
    Hung, Tung-Che
    Li, Chia -Wen
    Lee, Yuan -Ti
    Liou, Bo -Huang
    Yang, Chia-Jui
    Hung, Chien-Ching
    貢獻者: Far Eastern Memorial Hospital
    Fu Jen Catholic University
    National Taiwan University
    National Taiwan University Hospital
    National Taiwan University
    Chang Gung Memorial Hospital
    Chang Gung University
    Kaohsiung Medical University
    Kaohsiung Municipal Siao-Gang Hospital
    Kaohsiung Medical University
    Kaohsiung Medical University
    Changhua Christian Hospital
    Chi Mei Hospital
    Chia Nan University of Pharmacy & Science, Department of Health and Nutrition
    National Cheng Kung University
    National Cheng Kung University Hospital
    Chung Shan Medical University
    Chung Shan Medical University
    Chung Shan Medical University Hospital
    Mackay Memorial Hospital
    National Yang Ming Chiao Tung University
    National Taiwan University
    National Taiwan University
    National Taiwan University Hospital
    China Medical University Taiwan
    China Medical University Hospital - Taiwan
    China Medical University Taiwan
    關鍵字: hiv-1 reverse-transcriptase
    thymidine-analog mutations
    disoproxil fumarate
    k65r mutation
    日期: 2023
    上傳時間: 2023-12-11 13:59:52 (UTC+8)
    摘要: Objectives: Real-world experience with coformulated bictegravir, emtricitabine, and tenofovir alafenamide (BIC/FTC/TAF) is sparse as a switch regimen among people living with HIV (PLWH) having achieved viral suppression after previous virologic failures with the emergence of K65N/R.Methods: In this retrospective study, PLWH aged >20 years who had previous virologic failures with emergent K65N/R were included for switching to BIC/FTC/TAF after having achieved plasma HIV RNA load (PVL) < 200 copies/ml for >3 months. PLWH were excluded if integrase inhibitor resistance-associated mutations were detected. The primary end point was losing virologic control (PVL > 50 copies/ml) at week 48 using a modified US Food and Drug Administration snapshot algorithm.Results: A total of 72 PLWH with K65N/R who switched to BIC/FTC/TAF were identified. A total of 42 (59.7%) had concurrent M184V/I, and 9 (12.5%) had >1 thymidine analog mutations. The median dura-tion of viral suppression was 4.7 years (interquartile range 2.3-5.8), and 97.2% (n = 70) had PVL < 50 copies/ml before switching. After a median observation of 98.6 weeks (interquartile range 77.9-120.3), 94.4% (n = 68) continued BIC/FTC/TAF. At week 48, the rate of losing virologic control was 2.8% (2/72). M184V/I was not associated with viral rebound.Conclusion: Despite the emergence of K65N/R + /-M184V/I after virologic failures, BIC/FTC/TAF could be an option for simplification after viral suppression.(c) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
    Appears in Collections:[保健營養系(所) ] 期刊論文

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