The effect of adjuvant radiotherapy on clinical outcomes in early major salivary gland cancer

doi:10.1002/hed.27203

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/34591

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34591

Title:	The effect of adjuvant radiotherapy on clinical outcomes in early major salivary gland cancer
Authors:	Hong, Wei-Ju Chang, Shih-Lun Tsai, Chia-Jen Wu, Hung-Chang Chen, Yi-Chen Yang, Ching-Chieh Ho, Chung-Han
Contributors:	Chi Mei Hospital Chi Mei Hospital Chung Hua University Chi Mei Hospital Department of Pharmacy, Chia Nan University of Pharmacy & Science Chi Mei Hospital Southern Taiwan University of Science & Technology
Keywords:	postoperative radiation-therapy ex pleomorphic adenoma prognostic-factors parotid carcinoma survival surgery head tumors taiwan rates
Date:	2022
Issue Date:	2023-12-11 13:59:31 (UTC+8)
Publisher:	WILEY
Abstract:	Background This study investigated the effects of adjuvant radiotherapy on outcomes in early-stage major salivary gland cancers. Methods A total of 655 patients were identified, including 355 (54.2%) received adjuvant radiotherapy and 300 (45.8%) had surgery alone. The effect of adjuvant radiotherapy on 5-year locoregional recurrence and disease-specific survival (DSS) was calculated using the Kaplan-Meier method, Wilcoxon rank sum test, and Cox proportional hazards model. Results There were no significant differences in locoregional recurrence and DSS between patients receiving adjuvant radiotherapy and those not in both univariate and multivariable analysis. Although patients with positive margin status had a higher locoregional recurrence and those with moderate/poor differentiation had a worse DSS, stratified analysis still indicated there were no protective effects from the use of adjuvant radiotherapy. Conclusions The use of adjuvant radiation therapy was not associated with improved locoregional recurrence and DSS, even for those with high-risk histopathological factors.
Relation:	Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, v.44, n.12, pp.2865-2874
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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