A Population-Based Study of Social Demographic Factors, Associated Diseases and Recurrent Corneal Erosion in Taiwan

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Title:	A Population-Based Study of Social Demographic Factors, Associated Diseases and Recurrent Corneal Erosion in Taiwan
Authors:	Jan, Ren-Long Ho, Chung-Han Wang, Jhi-Joung Tseng, Sung-Huei Chang, Yuh-Shin
Contributors:	Chang Jung Christian University Chi Mei Hospital Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy & Science Southern Taiwan University of Science & Technology National Cheng Kung University National Cheng Kung University Hospital Chi Mei Hospital
Keywords:	eosinophil cationic protein confocal microscopy tears deposition
Date:	2022
Issue Date:	2023-12-11 13:59:23 (UTC+8)
Publisher:	FRONTIERS MEDIA SA
Abstract:	PurposeTo investigate the association of recurrent corneal erosion (RCE) with sociodemographic factors and associated ocular conditions or systemic diseases. MethodsThis nationwide, population-based, retrospective, matched case-controlled study included 98,895 RCE patients, identified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code 371.42, were selected from the Taiwan National Health Insurance Research Database. The age-, sex-, and index date- matched control group included 98,895 non-RCE control group also selected from the Taiwan Longitudinal Health Insurance Database 2000. Sociodemographic factors and associated ocular conditions or systemic diseases were examined using univariate logistic regression analyses, and continuous variables were analyzed using paired t-test. The odds ratio (OR) of developing RCE were compared using adjusted logistic regression analysis. ResultsPatients with ocular conditions including corneal abrasion, ocular allergic conditions, and corneal dystrophy were more likely to have RCE than the control group (adjusted OR = 63.56, 95% CI = 42.06-96.06, p < 0.0001; adjusted OR = 24.27, 95% CI = 20.51-28.72, p < 0.0001; adjusted OR = 17.10, 95% CI = 5.14-59.93, p < 0.0001, respectively). Patients with systemic diseases such as diabetes mellitus, hyperlipidaemia, and atopy trait have significantly higher ORs for RCE development. Patients residing in either Northern Taiwan or a metropolis city had higher odds of developing RCE; however, there were no significant differences in income or occupation on the probability to develop RCE. ConclusionRCE is strongly associated with corneal abrasion, ocular allergic conditions, corneal dystrophy, diabetes mellitus, hyperlipidaemia, and atopy trait.
Relation:	FRONTIERS IN PUBLIC HEALTH, v.10, Article 832333
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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