English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18054/20253 (89%)
Visitors : 24216426      Online Users : 59
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34587

    標題: Adjuvant chemotherapy and survival outcomes in rectal cancer patients with good response (ypT0-2N0) after neoadjuvant chemoradiotherapy and surgery: A retrospective nationwide analysis
    作者: Kuo, Yu-Hsuan
    Lin, Yun-Tzu
    Ho, Chung-Han
    Chou, Chia-Lin
    Cheng, Li-Chin
    Tsai, Chia-Jen
    Hong, Wei-Ju
    Chen, Yi-Chen
    Yang, Ching-Chieh
    貢獻者: Chi Mei Hospital
    Department of Cosmetic Science, Chia Nan University of Pharmacy & Science
    Chi Mei Hospital
    Southern Taiwan University of Science & Technology
    Chi Mei Hospital
    Chung Hua University
    Chi Mei Hospital
    Department of Pharmacy, Chia Nan University of Pharmacy & Science
    關鍵字: preoperative chemoradiotherapy
    postoperative chemoradiotherapy
    日期: 2022
    上傳時間: 2023-12-11 13:59:17 (UTC+8)
    摘要: Background: For rectal cancer, it remains unclear how to incorporate tumor response to neoadjuvant chemoradiotherapy (nCRT) when deciding whether to give adjuvant chemotherapy. In this study, we aim to determinate the survival benefit of adjuvant chemotherapy for rectal cancer patients with good response (ypT0-2N0) after nCRT and surgery. Methods: The study cohort included 720 rectal cancer patients who had good response (ypT0-2N0) after nCRT and surgery, who did or did not receive adjuvant chemotherapy between January 2007 and December 2017, from the Taiwan Cancer Registry and National Health Insurance Research database. The Kaplan-Meier method, log-rank tests, and Cox regression analysis were performed to investigate the effect of adjuvant chemotherapy on 5-year overall survival (OS) and disease-free survival (DFS). Results: Of 720 patients, 368 (51.1%) received adjuvant chemotherapy and 352 (48.9%) did not. Patients who received adjuvant chemotherapy were more likely to be female, younger (<= 65), with advanced clinical T (3-4)/N (1-2) classification and ypT2 classification. No significant difference in 5-year OS (p=0.681) or DFS (p=0.942) were observed by receipt of adjuvant chemotherapy or not. Multivariable analysis revealed adjuvant chemotherapy was not associated with better OS (adjusted hazard ratio [aHR], 1.03; 95% Confidence Interval [CI], 0.88-1.21) or DFS (aHR, 1.05; 95% CI, 0.89-1.24). Stratified analysis for OS and DFS found no significant protective effect in the use of adjuvant chemotherapy, even for those with advanced clinical T or N classification. Conclusion: Adjuvant chemotherapy may be omitted in rectal cancer patients with good response (ypT0-2N0) after nCRT and surgery.
    關聯: Frontiers in Oncology, v.12
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文
    [藥學系(所)] 期刊論文

    Files in This Item:

    File Description SizeFormat
    fonc.2022.1087778.pdf1110KbAdobe PDF42View/Open

    All items in CNU IR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback