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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34587


    標題: Adjuvant chemotherapy and survival outcomes in rectal cancer patients with good response (ypT0-2N0) after neoadjuvant chemoradiotherapy and surgery: A retrospective nationwide analysis
    作者: Kuo, Yu-Hsuan
    Lin, Yun-Tzu
    Ho, Chung-Han
    Chou, Chia-Lin
    Cheng, Li-Chin
    Tsai, Chia-Jen
    Hong, Wei-Ju
    Chen, Yi-Chen
    Yang, Ching-Chieh
    貢獻者: Chi Mei Hospital
    Department of Cosmetic Science, Chia Nan University of Pharmacy & Science
    Chi Mei Hospital
    Southern Taiwan University of Science & Technology
    Chi Mei Hospital
    Chung Hua University
    Chi Mei Hospital
    Department of Pharmacy, Chia Nan University of Pharmacy & Science
    關鍵字: preoperative chemoradiotherapy
    colorectal-cancer
    postoperative chemoradiotherapy
    tumor-regression
    colon-cancer
    stage-ii
    radiotherapy
    chemoradiation
    benefit
    trial
    日期: 2022
    上傳時間: 2023-12-11 13:59:17 (UTC+8)
    出版者: FRONTIERS MEDIA SA
    摘要: Background: For rectal cancer, it remains unclear how to incorporate tumor response to neoadjuvant chemoradiotherapy (nCRT) when deciding whether to give adjuvant chemotherapy. In this study, we aim to determinate the survival benefit of adjuvant chemotherapy for rectal cancer patients with good response (ypT0-2N0) after nCRT and surgery. Methods: The study cohort included 720 rectal cancer patients who had good response (ypT0-2N0) after nCRT and surgery, who did or did not receive adjuvant chemotherapy between January 2007 and December 2017, from the Taiwan Cancer Registry and National Health Insurance Research database. The Kaplan-Meier method, log-rank tests, and Cox regression analysis were performed to investigate the effect of adjuvant chemotherapy on 5-year overall survival (OS) and disease-free survival (DFS). Results: Of 720 patients, 368 (51.1%) received adjuvant chemotherapy and 352 (48.9%) did not. Patients who received adjuvant chemotherapy were more likely to be female, younger (<= 65), with advanced clinical T (3-4)/N (1-2) classification and ypT2 classification. No significant difference in 5-year OS (p=0.681) or DFS (p=0.942) were observed by receipt of adjuvant chemotherapy or not. Multivariable analysis revealed adjuvant chemotherapy was not associated with better OS (adjusted hazard ratio [aHR], 1.03; 95% Confidence Interval [CI], 0.88-1.21) or DFS (aHR, 1.05; 95% CI, 0.89-1.24). Stratified analysis for OS and DFS found no significant protective effect in the use of adjuvant chemotherapy, even for those with advanced clinical T or N classification. Conclusion: Adjuvant chemotherapy may be omitted in rectal cancer patients with good response (ypT0-2N0) after nCRT and surgery.
    關聯: Frontiers in Oncology, v.12
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文
    [藥學系(所)] 期刊論文

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