Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34586
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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34586


    Title: Chemical composition and anti-aging effects of standardized herbal chicken essence on D-galactose- induced senescent mice
    Authors: Wu, Shu-Jing
    Tung, Yi-Jou
    Yen, Ming-Hong
    Ng, Lean-Teik
    Contributors: Department of Nutritional Health, Chia Nan University of Pharmacy & Science
    Kaohsiung Medical University
    National Taiwan University
    Keywords: chronic inflammation
    oxidative stress
    ferulic acid
    sirt1
    supplementation
    restriction
    resveratrol
    antioxidant
    inhibition
    impairment
    Date: 2022
    Issue Date: 2023-12-11 13:59:14 (UTC+8)
    Publisher: FRONTIERS MEDIA SA
    Abstract: This study aimed to examine the chemical and anti-aging properties of chicken essence (CE) prepared with Sesamum indicum, Angelica acutiloba, and Zingiber officinale (HCE). HCE was analyzed for nutritional and phytochemical composition, and its anti-aging effects were investigated on the D-galactose (Gal)-induced aging mice. Results showed that HCE possessed significantly higher calories and contents of valine and total phenols than CE; it also contained significant amounts of ferulic acid, sesamin, and sesamolin. HCE significantly decreased MDA and NO levels in serum and liver and increased liver GSH levels in the D-Gal-induced mice. HCE greatly enhanced SOD and CAT activities in serum and liver, and liver GPx activity, as well as upregulating SIRT1 expression and downregulating TNF-alpha, IL-1 beta, IL-6, iNOS, Cox-2, and MCP-1 expression in liver tissues. This study demonstrates that HCE was effective in suppressing the aging process through enhancing antioxidant and anti-inflammatory activities and modulating the aging-related gene expression.
    Relation: FRONTIERS IN NUTRITION, v.9, n.CB2, pp.CC2, pp.-,
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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