Luteolin attenuates PM2.5-induced inflammatory responses by augmenting HO-1 and JAK-STAT expression in murine alveolar macrophages

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Title:	Luteolin attenuates PM2.5-induced inflammatory responses by augmenting HO-1 and JAK-STAT expression in murine alveolar macrophages
Authors:	Hsieh, Wen-Che Lai, Chane-Yu Lin, Hui-Wen Tu, Dom-Gene Shen, Ting-Jing Lee, Yi-Ju Hsieh, Ming-Chang Chen, Ching-Chung Han, Hsin-Hsuan Chang, Yuan-Yen
Contributors:	Chung Shan Medical University Chung Shan Medical University Hospital Asia University Taiwan China Medical University Taiwan China Medical University Hospital - Taiwan Department of Food Science and Technology, Chia Nan University of Pharmacy & Science Chang Jung Christian University
Keywords:	nf-kappa-b epithelial-cells a549 particulate matter antioxidant activities activation pm2.5 suppression involvement exposure pathway
Date:	2022
Issue Date:	2023-12-11 13:59:03 (UTC+8)
Publisher:	TAYLOR & FRANCIS LTD
Abstract:	To explore the involved mechanisms and possible treatments of ambient PM2.5 exposure-induced lung inflammation, this work studied the activity of luteolin, a natural flavonoid which widely presents in many plant species, in murine alveolar macrophage MH S cells exposed to PM2.5. Results showed PM2.5 induced an inflammatory response, as evidenced by significantly increased TNF-alpha, IL-6, MCP-1 and Rantes levels. and induced iNOS, COX-2, and NF-kappa B protein expressions in MH-S cells. Moreover, luteolin pre-treatment reduced JAK2 and STAT1 but not STAT3 protein expressions in PM2.5-stimulated MH-S cells. Performing JAK2 inhibitor AG490 further showed reduced TNF-alpha and IL-6 productions as well as iNOS, COX-2, and NF-kappa B protein expressions. In addition, although PM2.5 exposure could elevate HO-1 expression basically, luteolin pre-treatment and AG490 administration further significantly enhanced HO-1 expression additionally. Collectively, these results revealed that luteolin inhibits inflammation through suppressing JAK2/STAT1/NF-kappa B pathway and enhancing HO-1 expression in PM2.5-challenged alveolar macrophage MH-S cells.
Relation:	FOOD AND AGRICULTURAL IMMUNOLOGY, v.33, n.1, pp.47–64
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles

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