Luteolin attenuates PM2.5-induced inflammatory responses by augmenting HO-1 and JAK-STAT expression in murine alveolar macrophages

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Title:	Luteolin attenuates PM2.5-induced inflammatory responses by augmenting HO-1 and JAK-STAT expression in murine alveolar macrophages
Authors:	Hsieh, Wen-Che Lai, Chane-Yu Lin, Hui-Wen Tu, Dom-Gene Shen, Ting-Jing Lee, Yi-Ju Hsieh, Ming-Chang Chen, Ching-Chung Han, Hsin-Hsuan Chang, Yuan-Yen
Contributors:	Chung Shan Medical University Chung Shan Medical University Chung Shan Medical University Hospital Asia University Taiwan China Medical University Taiwan China Medical University Taiwan China Medical University Hospital - Taiwan Chia Nan University of Pharmacy & Science Chang Jung Christian University Chung Shan Medical University Chung Shan Medical University Chung Shan Medical University Hospital Chung Shan Medical University Chung Shan Medical University Chung Shan Medical University Hospital Chung Shan Medical University
Keywords:	nf-kappa-b epithelial-cells a549 particulate matter antioxidant activities activation pm2.5 suppression involvement exposure pathway
Date:	2022
Issue Date:	2023-12-11 13:59:03 (UTC+8)
Publisher:	TAYLOR & FRANCIS LTD
Abstract:	To explore the involved mechanisms and possible treatments of ambient PM2.5 exposure-induced lung inflammation, this work studied the activity of luteolin, a natural flavonoid which widely presents in many plant species, in murine alveolar macrophage MH S cells exposed to PM2.5. Results showed PM2.5 induced an inflammatory response, as evidenced by significantly increased TNF-alpha, IL-6, MCP-1 and Rantes levels. and induced iNOS, COX-2, and NF-kappa B protein expressions in MH-S cells. Moreover, luteolin pre-treatment reduced JAK2 and STAT1 but not STAT3 protein expressions in PM2.5-stimulated MH-S cells. Performing JAK2 inhibitor AG490 further showed reduced TNF-alpha and IL-6 productions as well as iNOS, COX-2, and NF-kappa B protein expressions. In addition, although PM2.5 exposure could elevate HO-1 expression basically, luteolin pre-treatment and AG490 administration further significantly enhanced HO-1 expression additionally. Collectively, these results revealed that luteolin inhibits inflammation through suppressing JAK2/STAT1/NF-kappa B pathway and enhancing HO-1 expression in PM2.5-challenged alveolar macrophage MH-S cells.
Relation:	FOOD AND AGRICULTURAL IMMUNOLOGY, v.33, n.CB2, pp.CC2, pp.-,
Appears in Collections:	[Offices] 123

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