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Please use this identifier to cite or link to this item:
https://ir.cnu.edu.tw/handle/310902800/34582
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標題: | Luteolin attenuates PM2.5-induced inflammatory responses by augmenting HO-1 and JAK-STAT expression in murine alveolar macrophages |
作者: | Hsieh, Wen-Che Lai, Chane-Yu Lin, Hui-Wen Tu, Dom-Gene Shen, Ting-Jing Lee, Yi-Ju Hsieh, Ming-Chang Chen, Ching-Chung Han, Hsin-Hsuan Chang, Yuan-Yen |
貢獻者: | Chung Shan Medical University Chung Shan Medical University Hospital Asia University Taiwan China Medical University Taiwan China Medical University Hospital - Taiwan Department of Food Science and Technology, Chia Nan University of Pharmacy & Science Chang Jung Christian University |
關鍵字: | nf-kappa-b epithelial-cells a549 particulate matter antioxidant activities activation pm2.5 suppression involvement exposure pathway |
日期: | 2022 |
上傳時間: | 2023-12-11 13:59:03 (UTC+8) |
出版者: | TAYLOR & FRANCIS LTD |
摘要: | To explore the involved mechanisms and possible treatments of ambient PM2.5 exposure-induced lung inflammation, this work studied the activity of luteolin, a natural flavonoid which widely presents in many plant species, in murine alveolar macrophage MH S cells exposed to PM2.5. Results showed PM2.5 induced an inflammatory response, as evidenced by significantly increased TNF-alpha, IL-6, MCP-1 and Rantes levels. and induced iNOS, COX-2, and NF-kappa B protein expressions in MH-S cells. Moreover, luteolin pre-treatment reduced JAK2 and STAT1 but not STAT3 protein expressions in PM2.5-stimulated MH-S cells. Performing JAK2 inhibitor AG490 further showed reduced TNF-alpha and IL-6 productions as well as iNOS, COX-2, and NF-kappa B protein expressions. In addition, although PM2.5 exposure could elevate HO-1 expression basically, luteolin pre-treatment and AG490 administration further significantly enhanced HO-1 expression additionally. Collectively, these results revealed that luteolin inhibits inflammation through suppressing JAK2/STAT1/NF-kappa B pathway and enhancing HO-1 expression in PM2.5-challenged alveolar macrophage MH-S cells. |
關聯: | FOOD AND AGRICULTURAL IMMUNOLOGY, v.33, n.1, pp.47–64 |
Appears in Collections: | [ 食品科技系 ] 期刊論文
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