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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34582


    標題: Luteolin attenuates PM2.5-induced inflammatory responses by augmenting HO-1 and JAK-STAT expression in murine alveolar macrophages
    作者: Hsieh, Wen-Che
    Lai, Chane-Yu
    Lin, Hui-Wen
    Tu, Dom-Gene
    Shen, Ting-Jing
    Lee, Yi-Ju
    Hsieh, Ming-Chang
    Chen, Ching-Chung
    Han, Hsin-Hsuan
    Chang, Yuan-Yen
    貢獻者: Chung Shan Medical University
    Chung Shan Medical University Hospital
    Asia University Taiwan
    China Medical University Taiwan
    China Medical University Hospital - Taiwan
    Department of Food Science and Technology, Chia Nan University of Pharmacy & Science
    Chang Jung Christian University
    關鍵字: nf-kappa-b
    epithelial-cells a549
    particulate matter
    antioxidant activities
    activation
    pm2.5
    suppression
    involvement
    exposure
    pathway
    日期: 2022
    上傳時間: 2023-12-11 13:59:03 (UTC+8)
    出版者: TAYLOR & FRANCIS LTD
    摘要: To explore the involved mechanisms and possible treatments of ambient PM2.5 exposure-induced lung inflammation, this work studied the activity of luteolin, a natural flavonoid which widely presents in many plant species, in murine alveolar macrophage MH S cells exposed to PM2.5. Results showed PM2.5 induced an inflammatory response, as evidenced by significantly increased TNF-alpha, IL-6, MCP-1 and Rantes levels. and induced iNOS, COX-2, and NF-kappa B protein expressions in MH-S cells. Moreover, luteolin pre-treatment reduced JAK2 and STAT1 but not STAT3 protein expressions in PM2.5-stimulated MH-S cells. Performing JAK2 inhibitor AG490 further showed reduced TNF-alpha and IL-6 productions as well as iNOS, COX-2, and NF-kappa B protein expressions. In addition, although PM2.5 exposure could elevate HO-1 expression basically, luteolin pre-treatment and AG490 administration further significantly enhanced HO-1 expression additionally. Collectively, these results revealed that luteolin inhibits inflammation through suppressing JAK2/STAT1/NF-kappa B pathway and enhancing HO-1 expression in PM2.5-challenged alveolar macrophage MH-S cells.
    關聯: FOOD AND AGRICULTURAL IMMUNOLOGY, v.33, n.1, pp.47–64
    Appears in Collections:[ 食品科技系 ] 期刊論文

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