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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34581


    標題: Novel insights into the anti-cancer effects of 3-bromopyruvic acid against castration-resistant prostate cancer
    作者: Yeh, Hsin-Chih
    Su, Chia-Cheng
    Wu, Yen-Hsuan
    Lee, Cheng Hsueh
    Bao, Bo-Ying
    Cheng, Wei-Chung
    Wang, Shu-Chi
    Liu, Po-Len
    Chiu, Chien-Chih
    Chuu, Chih-Pin
    Ke, Chien-Chih
    Wu, Hsin-En
    Chen, Yuan-Ru
    Chung, Wei-Ju
    Huang, Shu-Pin
    Li, Chia-Yang
    貢獻者: Kaohsiung Medical University
    Kaohsiung Medical University Hospital
    Kaohsiung Municipal Ta-Tung Hospital
    Chi Mei Hospital
    Department of Senior Citizen Service Management, Chia Nan University of Pharmacy & Science
    China Medical University Taiwan
    China Medical University Hospital - Taiwan
    Asia University Taiwan
    China Medical University Taiwan
    Kaohsiung Medical University
    National Health Research Institutes - Taiwan
    關鍵字: cell-cycle arrest
    apoptosis
    therapy
    agent
    model
    mcf-7
    line
    日期: 2022
    上傳時間: 2023-12-11 13:59:00 (UTC+8)
    出版者: ELSEVIER
    摘要: 3-bromopyruvic acid (3-BP), a small molecule alkylating agent, has been emerged as a glycolytic inhibitor with anticancer activities. However, the effects of 3-BP on the growth and metastasis in prostate cancer have not been well investigated. Here we investigated the anti-cancer effects of 3-BP on prostate cancer in vitro and in vivo. Cell growth, apoptosis, migration, motility, and invasion were examined. The tumor growth ability was determined using a xenograft murine model. Transcriptome analysis using RNA-seq was performed to explore the mechanism of action of 3-BP. Our experimental results showed that 3-BP effectively inhibits prostate cancer cell growth, especially in castration-resistant prostate cancer (CRPC) cells. Moreover, 3-BP induces apoptosis and suppresses cell migration, motility, epithelial-mesenchymal transition (EMT), and invasion in CRPC cells. In addition, 3-BP also attenuates tumor growth in a xenograft murine model. Through transcriptome analysis using RNA-seq, 3-BP significantly regulates the cell cycle pathway and decreases the expression of downstream cycle cycle-associated genes in CRPC cells. The results of cell cycle analysis indicated that 3-BP arrests cell cycle progression at G2/M in CRPC cells. These results suggest that 3-BP has the potential in inhibiting CRPC progression and might be a promising drug for CRPC treatment.
    關聯: EUROPEAN JOURNAL OF PHARMACOLOGY, v.923,174929CB2
    Appears in Collections:[高齡福祉養生管理系] 期刊論文

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