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| 標題: | Novel insights into the anti-cancer effects of 3-bromopyruvic acid against castration-resistant prostate cancer |
| 作者: | Yeh, Hsin-Chih
Su, Chia-Cheng
Wu, Yen-Hsuan
Lee, Cheng Hsueh
Bao, Bo-Ying
Cheng, Wei-Chung
Wang, Shu-Chi
Liu, Po-Len
Chiu, Chien-Chih
Chuu, Chih-Pin
Ke, Chien-Chih
Wu, Hsin-En
Chen, Yuan-Ru
Chung, Wei-Ju
Huang, Shu-Pin
Li, Chia-Yang |
| 貢獻者: | Kaohsiung Medical University
Kaohsiung Medical University Hospital
Kaohsiung Municipal Ta-Tung Hospital
Chi Mei Hospital
Department of Senior Citizen Service Management, Chia Nan University of Pharmacy & Science
China Medical University Taiwan
China Medical University Hospital - Taiwan
Asia University Taiwan
China Medical University Taiwan
Kaohsiung Medical University
National Health Research Institutes - Taiwan |
| 關鍵字: | cell-cycle arrest
apoptosis
therapy
agent
model
mcf-7
line |
| 日期: | 2022 |
| 上傳時間: | 2023-12-11 13:59:00 (UTC+8) |
| 出版者: | ELSEVIER |
| 摘要: | 3-bromopyruvic acid (3-BP), a small molecule alkylating agent, has been emerged as a glycolytic inhibitor with anticancer activities. However, the effects of 3-BP on the growth and metastasis in prostate cancer have not been well investigated. Here we investigated the anti-cancer effects of 3-BP on prostate cancer in vitro and in vivo. Cell growth, apoptosis, migration, motility, and invasion were examined. The tumor growth ability was determined using a xenograft murine model. Transcriptome analysis using RNA-seq was performed to explore the mechanism of action of 3-BP. Our experimental results showed that 3-BP effectively inhibits prostate cancer cell growth, especially in castration-resistant prostate cancer (CRPC) cells. Moreover, 3-BP induces apoptosis and suppresses cell migration, motility, epithelial-mesenchymal transition (EMT), and invasion in CRPC cells. In addition, 3-BP also attenuates tumor growth in a xenograft murine model. Through transcriptome analysis using RNA-seq, 3-BP significantly regulates the cell cycle pathway and decreases the expression of downstream cycle cycle-associated genes in CRPC cells. The results of cell cycle analysis indicated that 3-BP arrests cell cycle progression at G2/M in CRPC cells. These results suggest that 3-BP has the potential in inhibiting CRPC progression and might be a promising drug for CRPC treatment. |
| 關聯: | EUROPEAN JOURNAL OF PHARMACOLOGY, v.923,174929CB2 |
| 顯示於類別: | [高齡福祉養生管理系] 期刊論文
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