Unusually high incidence of polyomavirus JC infection in the higher grade of colorectal cancer tissues in Taiwan

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標題:	Unusually high incidence of polyomavirus JC infection in the higher grade of colorectal cancer tissues in Taiwan
作者:	Fang, Chuan-Yin Chen, San-Yuan Hsiao, Bo-Xiu Huang, Hsin-Yi Chen, Yi-Ju Tung, Chun-Liang Fang, Chiung-Yao
貢獻者:	Chia-Yi Christian Hospital Department of Sports Management, Chia Nan University of Pharmacy & Science Chia-Yi Christian Hospital Chia-Yi Christian Hospital Asia University Taiwan
關鍵字:	large t-antigens colon-cancer virus-dna association pathogenesis carcinoma sequences pathways
日期:	2022
上傳時間:	2023-12-11 13:58:58 (UTC+8)
出版者:	BMC
摘要:	Introduction The human JC polyomavirus (JCPyV) has been detected in colorectal cancer (CRC) tissues and is suggested to contribute to CRC tumorigenesis. The rearrangement of the JCPyV regulatory region is supposedly associated with CRC development. The progression of CRC involves the stepwise accumulation of mutations. The large tumor antigen (LT) of JCPyV can trigger uncontrolled cell cycle progression by targeting oncogenes, and tumor suppressor genes, and causing chromosome instability. Few studies have focused on the presence of JCPyV DNA in the higher grade of CRC tissues. Methods We collected 95 tissue blocks from samples of stages I, II, III, and IV CRC. Nested PCR targeting the regulatory region of the viral genome was performed to determine the presence of JCPyV DNA in the various stages of colorectal cancer tissues. Results The nested PCR results showed that the positive rate of JCPyV DNA increased with the progression of CRC stages. The archetypal-like, non-rearrangement genotype of JCPyV with subtle mutations was the major genotype found in CRC samples. Conclusions This finding in our study suggests that there may be an association between JCPyV and CRC progression.
關聯:	EUROPEAN JOURNAL OF MEDICAL RESEARCH, v.27, Article number: 1277
顯示於類別:	[運動管理系] 期刊論文

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