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    题名: Changing epidemiology of shigellosis in Taiwan, 2010-2019: an emerging threat to HIV-infected patients and men who have sex with men
    作者: Tsai, Chin-Shiang
    Lin, Kuan-Yin
    Liou, Bo-Huang
    Chiou, Chien-Shun
    Lin, Yi-Chun
    Lee, Yuan-Ti
    Yang, Chia-Jui
    Tang, Hung-Jen
    Liao, Ying-Shu
    Liu, Chun-Eng
    Lee, Chen-Hsiang
    Lu, Po-Liang
    Huang, Sung-Hsi
    Hung, Chien-Ching
    Ko, Wen-Chien
    贡献者: National Cheng Kung University
    National Cheng Kung University
    National Cheng Kung University Hospital
    National Cheng Kung University
    National Cheng Kung University Hospital
    National Taiwan University
    National Taiwan University Hospital
    National Taiwan University
    National Taiwan University Hospital
    Mackay Memorial Hospital
    Centers For Disease Control - Taiwan
    Chung Shan Medical University
    Chung Shan Medical University Hospital
    Chung Shan Medical University
    National Yang Ming Chiao Tung University
    Far Eastern Memorial Hospital
    Chi Mei Hospital
    Department of Health and Nutrition, Chia Nan University of Pharmacy & Science
    Changhua Christian Hospital
    Chang Gung Memorial Hospital
    Chang Gung University
    Kaohsiung Medical University
    Kaohsiung Medical University Hospital
    Kaohsiung Medical University
    National Taiwan University
    National Taiwan University Hospital
    National Taiwan University
    China Medical University Taiwan
    China Medical University Hospital - Taiwan
    China Medical University Taiwan
    National Cheng Kung University
    关键词: antimicrobial susceptibility patterns
    diseases society
    surveillance
    transmission
    flexneri
    guidelines
    resistance
    england
    america
    3a
    日期: 2022
    上传时间: 2023-12-11 13:58:54 (UTC+8)
    出版者: TAYLOR & FRANCIS LTD
    摘要: Shigellosis appears to increase in certain at-risk populations in developed countries. Based on the nationwide surveillance, the annual incidence of shigellosis in Taiwan (1999-2019) was 0.38-5.77 cases per 100,000 people. Indigenous shigellosis has mostly affected men who have sex with men (MSM) and people living with HIV (PLWH) since 2015. In this retrospective study, compared with those diagnosed before 2015, indigenous cases diagnosed during 2015-2019 mostly occurred in male adults (96.0% vs 47.1%, P < 0.001), with a longer hospital stay (median 5.0 vs 3.5 days, P = 0.029) and different coinfections. The predominant strains in 2015 and 2016 were ciprofloxacin-resistant Shigella sonnei and azithromycin non-susceptible Shigella flexneri (S. flexneri) 3a, which had been replaced by ciprofloxacin-resistant S. flexneri 2a since 2018. Notably, six indigenous cases were caused by cefotaxime-resistant S. flexneri. Inappropriate use of empiric antibiotic treatment was common. In conclusion, there is an ongoing spread of ciprofloxacin-resistant shigellosis among PLWH and MSM and cefotaxime-resistant S. flexneri is an emerging threat in Taiwan.
    關聯: EMERGING MICROBES & INFECTIONS, v.11, Issue 1, pp.498-506
    显示于类别:[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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