Changing epidemiology of shigellosis in Taiwan, 2010-2019: an emerging threat to HIV-infected patients and men who have sex with men

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Title:	Changing epidemiology of shigellosis in Taiwan, 2010-2019: an emerging threat to HIV-infected patients and men who have sex with men
Authors:	Tsai, Chin-Shiang Lin, Kuan-Yin Liou, Bo-Huang Chiou, Chien-Shun Lin, Yi-Chun Lee, Yuan-Ti Yang, Chia-Jui Tang, Hung-Jen Liao, Ying-Shu Liu, Chun-Eng Lee, Chen-Hsiang Lu, Po-Liang Huang, Sung-Hsi Hung, Chien-Ching Ko, Wen-Chien
Contributors:	National Cheng Kung University National Cheng Kung University National Cheng Kung University Hospital National Cheng Kung University National Cheng Kung University Hospital National Taiwan University National Taiwan University Hospital National Taiwan University National Taiwan University Hospital Mackay Memorial Hospital Centers For Disease Control - Taiwan Chung Shan Medical University Chung Shan Medical University Hospital Chung Shan Medical University National Yang Ming Chiao Tung University Far Eastern Memorial Hospital Chi Mei Hospital Department of Health and Nutrition, Chia Nan University of Pharmacy & Science Changhua Christian Hospital Chang Gung Memorial Hospital Chang Gung University Kaohsiung Medical University Kaohsiung Medical University Hospital Kaohsiung Medical University National Taiwan University National Taiwan University Hospital National Taiwan University China Medical University Taiwan China Medical University Hospital - Taiwan China Medical University Taiwan National Cheng Kung University
Keywords:	antimicrobial susceptibility patterns diseases society surveillance transmission flexneri guidelines resistance england america 3a
Date:	2022
Issue Date:	2023-12-11 13:58:54 (UTC+8)
Publisher:	TAYLOR & FRANCIS LTD
Abstract:	Shigellosis appears to increase in certain at-risk populations in developed countries. Based on the nationwide surveillance, the annual incidence of shigellosis in Taiwan (1999-2019) was 0.38-5.77 cases per 100,000 people. Indigenous shigellosis has mostly affected men who have sex with men (MSM) and people living with HIV (PLWH) since 2015. In this retrospective study, compared with those diagnosed before 2015, indigenous cases diagnosed during 2015-2019 mostly occurred in male adults (96.0% vs 47.1%, P < 0.001), with a longer hospital stay (median 5.0 vs 3.5 days, P = 0.029) and different coinfections. The predominant strains in 2015 and 2016 were ciprofloxacin-resistant Shigella sonnei and azithromycin non-susceptible Shigella flexneri (S. flexneri) 3a, which had been replaced by ciprofloxacin-resistant S. flexneri 2a since 2018. Notably, six indigenous cases were caused by cefotaxime-resistant S. flexneri. Inappropriate use of empiric antibiotic treatment was common. In conclusion, there is an ongoing spread of ciprofloxacin-resistant shigellosis among PLWH and MSM and cefotaxime-resistant S. flexneri is an emerging threat in Taiwan.
Relation:	EMERGING MICROBES & INFECTIONS, v.11, Issue 1, pp.498-506
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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