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| 標題: | Outcomes associated with acute kidney disease: A systematic review and meta-analysis |
| 作者: | Su, Ching-Chun
Chen, Jui-Yi
Chen, Sheng-Yin
Shiao, Chih-Chung
Neyra, Javier A.
Matsuura, Ryo
Noiri, Eisei
See, Emily
Chen, Yih-Ting
Hsu, Cheng-Kai
Pan, Heng-Chih
Chang, Chih-Hsiang
Rosner, Mitchell H.
Wu, Vin-Cent |
| 貢獻者: | Chi Mei Hospital
Chia Nan University of Pharmacy & Science,b
Department of Health and Nutrition
Harvard University
Harvard T.H. Chan School of Public Health
University of Alabama System
University of Alabama Birmingham
University of Tokyo
National Center for Global Health & Medicine - Japan
Royal Melbourne Hospital
Royal Melbourne Hospital
Chang Gung Memorial Hospital
Chang Gung Memorial Hospital
National Taiwan University
National Taiwan University Hospital
National Taiwan University
National Taiwan University Hospital |
| 關鍵字: | long-term outcomes
injury
recovery
sepsis
care |
| 日期: | 2023 |
| 上傳時間: | 2023-12-11 13:58:42 (UTC+8) |
| 出版者: | ELSEVIER |
| 摘要: | Background Acute kidney disease (AKD) defines the period after kidney damage and it is a critical period of both repair and fibrotic pathways. However, the outcomes of patients with AKD have not been well-defined.Methods In this meta-analysis, PubMed, Embase, Cochrane and China National Knowledge Infrastructure were searched on July 31,2022. We excluded studies including patients undergoing kidney replacement therapy at enrollment. The data was used to conduct a random-effects model for pool outcomes between patients with AKD and non-AKD (NKD). This study is registered with PROSPERO, CRD 42021271773.Findings The search generated 739 studies of which 21 studies were included involving 1,114,012 patients. The incidence rate of community-acquired AKD was 4.60%, 2.11% in hospital-acquired AKD without a prior AKI episode, and 26.11% in hospital-acquired AKD with a prior AKI episode. The all-cause mortality rate was higher in the AKD group (26.54%) than in the NKD group (7.78%) (odds ratio [OR]: 3.62, 95% confidence interval [CI]: 2.64 to 4.95, p < 0.001, I2 = 99.11%). The rate of progression to end-stage kidney disease (ESKD) was higher in the AKD group (1.3%) than in the NKD group (0.14%) (OR: 6.58, p < 0.001, I2 = 94.95%). The incident rate of CKD and progressive CKD was higher in the AKD group (37.2%) than in the NKD group (7.45%) (OR:4.22, p < 0.001, I2 = 96.67%). Compared to the NKD group, patients with AKD without prior AKI had a higher mortality rate (OR: 3.00, p < 0.001, I2 = 99.31%) and new-onset ESKD (OR:4.96, 95% CI, p = 0.002, I2 = 97.37%).Interpretation AKD is common in community and hospitalized patients who suffer from AKI and also occurs in patients without prior AKI. The patients with AKD, also in those without prior AKI had a higher risk of mortality, and new-onset ESKD than the NKD group.Funding This study was supported by Ministry of Science and Technology (MOST) of the Republic of China (Taiwan) [grant number, MOST 107-2314-B-002-026-MY3, 108-2314-B-002-058, 110-2314-B-002-241, 110-2314-B-002-239], National Science and Technology Council (NSTC) [grant number, NSTC 109-2314-B-002-174-MY3, 110-2314-B-002-124-MY3, 111-2314-B-002-046, 111-2314-B-002-058], National Health Research Institutes [PH-102-SP-09], National Taiwan University Hospital [109-S4634, PC-1246, PC-1309, VN109-09, UN109-041, UN110-030, 111 -2023;55: FTN0011] Grant MOHW110-TDU-B-212-124005, Mrs. Hsiu-Chin Lee Kidney Research Fund and Chi-mei medical center CMFHR11136. JAN is supported, in part, by grants from the National Institute of Health, NIDDK (R01 DK128208 and P30 DK079337) and NHLBI (R01 HL148448-01).Copyright (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| 關聯: | ECLINICALMEDICINE, v.55, January 2023, 101760 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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