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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34571

    標題: The Added Value of Intraventricular Hemorrhage on the Radiomics Analysis for the Prediction of Hematoma Expansion of Spontaneous Intracerebral Hemorrhage
    作者: Wu, Te-Chang
    Liu, Yan-Lin
    Chen, Jeon-Hor
    Zhang, Yang
    Chen, Tai-Yuan
    Ko, Ching-Chung
    Su, Min-Ying
    貢獻者: Chi Mei Hospital
    Chang Jung Christian University
    University of California System
    University of California Irvine
    E-Da Hospital
    I Shou University
    Rutgers System
    Rutgers New Brunswick
    Rutgers Biomedical & Health Sciences
    Rutgers Cancer Institute of New Jersey
    Chang Jung Christian University
    Chia Nan University of Pharmacy & Science, Center of General Education
    關鍵字: noncontrast computed-tomography
    angiography spot sign
    日期: 2022
    上傳時間: 2023-12-11 13:58:28 (UTC+8)
    出版者: MDPI
    摘要: Background: Among patients undergoing head computed tomography (CT) scans within 3 h of spontaneous intracerebral hemorrhage (sICH), 28% to 38% have hematoma expansion (HE) on follow-up CT. This study aimed to predict HE using radiomics analysis and investigate the impact of intraventricular hemorrhage (IVH) compared with the conventional approach based on intraparenchymal hemorrhage (IPH) alone. Methods: This retrospective study enrolled 127 patients with baseline and follow-up non-contrast CT (NCCT) within 4 similar to 72 h of sICH. IPH and IVH were outlined separately for performing radiomics analysis. HE was defined as an absolute hematoma growth > 6 mL or percentage growth > 33% of either IPH (HEP) or a combination of IPH and IVH (HEP+V) at follow-up. Radiomic features were extracted using PyRadiomics, and then the support vector machine (SVM) was used to build the classification model. For each case, a radiomics score was generated to indicate the probability of HE. Results: There were 57 (44.9%) HEP and 70 (55.1%) non-HEP based on IPH alone, and 58 (45.7%) HEP+V and 69 (54.3%) non-HEP+V based on IPH + IVH. The majority (>94%) of HE patients had poor early outcomes (death or modified Rankin Scale > 3 at discharge). The radiomics model built using baseline IPH to predict HEP (RMP) showed 76.4% accuracy and 0.73 area under the ROC curve (AUC). The other model using IPH + IVH to predict HEP+V (RMP+V) had higher accuracy (81.9%) with AUC = 0.80, and this model could predict poor outcomes. The sensitivity/specificity of RMP and RMP+V for HE prediction were 71.9%/80.0% and 79.3%/84.1%, respectively. Conclusion: The proposed radiomics approach with additional IVH information can improve the accuracy in prediction of HE, which is associated with poor clinical outcomes. A reliable radiomics model may provide a robust tool to help manage ICH patients and to enroll high-risk ICH cases into anti-expansion or neuroprotection drug trials.
    關聯: DIAGNOSTICS, v.12, n.11, 2755
    Appears in Collections:[通識教育中心] 期刊論文

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