Association of Prognostic Nutritional Index with Severity and Mortality of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis

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標題:	Association of Prognostic Nutritional Index with Severity and Mortality of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis
作者:	Hung, Kuo-Chuan Ko, Ching-Chung Wang, Li-Kai Liu, Ping-Hsin Chen, I-Wen Huang, Yen-Ta Sun, Cheuk-Kwan
貢獻者:	Chi Mei Hospital Department of Health and Nutrition, Chia Nan University of Pharmacy & Science Chi Mei Hospital Chia Nan University of Pharmacy & Science National Sun Yat Sen University E-Da Hospital National Cheng Kung University National Cheng Kung University Hospital E-Da Hospital I Shou University
關鍵字:	inflammation morbidity length stay
日期:	2022
上傳時間:	2023-12-11 13:58:21 (UTC+8)
出版者:	MDPI
摘要:	The associations of prognostic nutritional index (PNI) with disease severity and mortality in patients with coronavirus disease 2019 (COVID-19) remain unclear. Electronic databases, including MEDLINE, EMBASE, Google scholar, and Cochrane Library, were searched from inception to 10 May 2022. The associations of PNI with risk of mortality (primary outcome) and disease severity (secondary outcome) were investigated. Merged results from meta-analysis of 13 retrospective studies (4204 patients) published between 2020 and 2022 revealed a lower PNI among patients in the mortality group [mean difference (MD): -8.65, p < 0.001] or severity group (MD: -5.19, p < 0.001) compared to those in the non-mortality or non-severity groups. A per-point increase in PNI was associated with a reduced risk of mortality [odds ratio (OR) = 0.84, 95% CI: 0.79 to 0.9, p < 0.001, I-2 = 67.3%, seven studies] and disease severity (OR = 0.84, 95% CI: 0.77 to 0.92, p < 0.001, I-2 = 83%, five studies). The pooled diagnostic analysis of mortality yielded a sensitivity of 0.76, specificity of 0.71, and area under curve (AUC) of 0.79. Regarding the prediction of disease severity, the sensitivity, specificity, and AUC were 0.8, 0.61, and 0.65, respectively. In conclusion, this study demonstrated a negative association between PNI and prognosis of COVID-19. Further large-scale trials are warranted to support our findings.
關聯:	DIAGNOSTICS, v.12, n.7, 1515
Appears in Collections:	[保健營養系(所) ] 期刊論文

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