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| 標題: | Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis |
| 作者: | Hung, Kuo-Chuan
Huang, Yen-Ta
Chang, Ying-Jen
Yu, Chia-Hung
Wang, Li-Kai
Wu, Chung-Yi
Liu, Ping-Hsin
Chiu, Sheng-Fu
Sun, Cheuk-Kwan |
| 貢獻者: | Chi Mei Hospital
Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy & Science
National Cheng Kung University
National Cheng Kung University Hospital
Department of Recreation and Health-Care Management, Chia Nan University of Pharmacy & Science
E-Da Hospital
Chi Mei Hospital
E-Da Hospital
I Shou University |
| 關鍵字: | disease severity
markers
predictors
biomarker
mortality
length
stay |
| 日期: | 2022 |
| 上傳時間: | 2023-12-11 13:58:18 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | Although the fibrinogen-to-albumin ratio (F/R ratio) has been used as an inflammation marker to predict clinical outcomes in patients with cardiovascular diseases, its association with the prognosis of patients with coronavirus disease 2019 (COVID-19) remains unclear. Electronic databases including EMBASE, MEDLINE, Google Scholar, and Cochrane Library were searched from inception to 20 June 2022. The associations of F/R ratio with poor prognosis (defined as the occurrence of mortality or severe disease) were investigated in patients with COVID-19. A total of 10 studies (seven from Turkey, two from China, one from Croatia) involving 3675 patients published between 2020 and 2022 were eligible for quantitative syntheses. Merged results revealed a higher F/R ratio in the poor prognosis group (standardized mean difference: 0.529, p < 0.001, I-2 = 84.8%, eight studies) than that in the good prognosis group. In addition, a high F/R ratio was associated with an increased risk of poor prognosis (odds ratio: 2.684, I-2 = 59.5%, five studies). Pooled analysis showed a sensitivity of 0.75, specificity of 0.66, and area under curve of 0.77 for poor prognosis prediction. In conclusion, this meta-analysis revealed a positive correlation between F/A ratio and poor prognostic outcomes of COVID-19. Because of the limited number of studies included, further investigations are warranted to support our findings. |
| 關聯: | Diagnostics, v.12, n.7, 1678 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
[休閒保健管理系(所)] 期刊論文
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