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| 標題: | Association of sepsis-induced cardiomyopathy and mortality: a systematic review and meta-analysis |
| 作者: | Lin, Yu-Min
Lee, Mei-Chuan
Toh, Han Siong
Chang, Wei-Ting
Chen, Sih-Yao
Kuo, Fang-Hsiu
Tang, Hsin-Ju
Hua, Yi-Ming
Wei, Dongmei
Melgarejo, Jesus
Zhang, Zhen-Yu
Liao, Chia-Te |
| 貢獻者: | Chi Mei Hospital
Chi Mei Hospital
National Cheng Kung University
Chi Mei Hospital
National Cheng Kung University
Department of Health and Nutrition, Chia Nan University of Pharmacy & Science
Southern Taiwan University of Science & Technology
Chang Gung University of Science & Technology
KU Leuven |
| 關鍵字: | ventricular systolic dysfunction
septic shock
diastolic dysfunction
myocardial dysfunction
ejection fraction
performance
outcomes |
| 日期: | 2022 |
| 上傳時間: | 2023-12-11 13:56:26 (UTC+8) |
| 出版者: | SPRINGER |
| 摘要: | Background: The implication of sepsis-induced cardiomyopathy (SIC) to prognosis is controversial, and its association with mortality at different stages remains unclear. We conducted a systematic review and meta-analysis to understand the association between SIC and mortality in septic patients. Methods: We searched and appraised observational studies regarding the mortality related to SIC among septic patients in PubMed and Embase from inception until 8 July 2021. Outcomes comprised in-hospital and 1-month mortality. We adopted the random-effects model to examine the mortality risk ratio in patients with and without SIC. Meta-regression, subgroup, and sensitivity analyses were applied to examine the outcome's heterogeneity. Results: Our results, including 20 studies and 4,410 septic patients, demonstrated that SIC was non-statistically associated with increased in-hospital mortality, compared to non-SIC (RR 1.28, [0.96-1.71]; p = 0.09), but the association was statistically significant in patients with the hospital stay lengths longer than 10 days (RR 1.40, [1.02-1.93]; p = 0.04). Besides, SIC was significantly associated with a higher risk of 1-month mortality (RR 1.47, [1.17-1.86]; p < 0.01). Among SIC patients, right ventricular dysfunction was significantly associated with increased 1-month mortality (RR 1.72, [1.27-2.34]; p < 0.01), while left ventricular dysfunction was not (RR 1.33, [0.87-2.02]; p = 0.18). Conclusions: With higher in-hospital mortality in those hospitalized longer than 10 days and 1-month mortality, our findings imply that SIC might continue influencing the host's system even after recovery from cardiomyopathy. Besides, right ventricular dysfunction might play a crucial role in SIC-related mortality, and timely biventricular assessment is vital in managing septic patients. |
| 關聯: | ANNALS OF INTENSIVE CARE, v.12, n.CB2, pp.CC2, pp.-2737, |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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