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| 標題: | Low expression of cytosolic NOTCH1 predicts poor prognosis of breast cancer patients |
| 作者: | Chen, Yi-Ling
Lee, Kuo-Ting
Wang, Chih-Yang
Shen, Che-Hung
Chen, Sheau-Chiann
Chung, Wei-Pang
Hsu, Ya-Ting
Kuo, Yao-Lung
Chen, Pai-Sheng
Cheung, Chun Hei Antonio
Chang, Chih-Peng
Shen, Meng-Ru
Hsu, Hui-Ping |
| 貢獻者: | Department of Health and Nutrition, Chia Nan University of Pharmacy & Science
National Cheng Kung University
National Cheng Kung University Hospital
National Health Research Institutes - Taiwan
Vanderbilt University |
| 關鍵字: | tumor-suppressor
young-women
metastasis
signature
survival
subtypes
taiwan
axis
p53 |
| 日期: | 2022 |
| 上傳時間: | 2023-12-11 13:56:01 (UTC+8) |
| 出版者: | E-CENTURY PUBLISHING CORP |
| 摘要: | The incidence of breast cancer is increasing, and is one of the leading causes of cancer death worldwide. Dysregulation of NOTCH1 signaling is reported in breast cancer. In present study, bioinformatics was utilized to study the expression of NOTCH1 gene in breast cancer from public databases, including the Kaplan-Meier Plotter, PrognoScan, Human Protein Atlas, and cBioPortal. The relationship between NOTCH1 mRNA expression and survival of patients was inconsistent in public databases. In addition, we performed immunohistochemistry (IHC) staining of 135 specimens from our hospital. Lower cytoplasmic staining of NOTCH1 protein was correlated with cancer recurrence, bone metastasis, and a worse disease-free survival of patients, especially those with estrogen receptor-positive and human epidermal growth factor receptor 2-positive (HER2(+)) cancers. In TCGA breast cancer dataset, lower expression of NOTCH1 in breast cancer specimens was correlated with higher level of CCND1 (protein: cyclin D1). Decreased expression of NOTCH1 was correlated with lower level of CCNA1 (protein: cyclin A1), CCND2 (protein: cyclin D2), CCNE1 (protein: cyclin E1), CDK6 (protein: CDK6), and CDKN2C (protein: p18). In conclusion, NOTCH1 mRNA expression is not consistently correlated with clinical outcomes of breast cancer patients. Low cytoplasmic expression of NOTCH1 in IHC study is correlated with poor prognosis of breast cancer patients. Cytoplasmic localization of NOTCH1 protein failed to initial oncogenic signaling in present study. Expression of NOTCH1 mRNA was discordant with cell cycle-related genes. Regulation of NOTCH1 in breast cancer involves gene expression, protein localization and downstream signaling. |
| 關聯: | American Journal of Cancer Research, v.12, n.5, pp.2084–2101 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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