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https://ir.cnu.edu.tw/handle/310902800/34518
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| 標題: | Optimal Lymph Node Yield for Survival Prediction in Rectal Cancer Patients After Neoadjuvant Therapy |
| 作者: | Lin, Yu-Min
Chou, Chia-Lin
Kuo, Yu-Hsuan
Wu, Hung-Chang
Tsai, Chia-Jen
Ho, Chung-Han
Chen, Yi-Chen
Yang, Ching-Chieh
Lin, Cheng-Wei |
| 貢獻者: | Chi Mei Med Ctr, Dept Internal Med, Div Hepatogastroenterol
Chi Mei Med Ctr, Dept Surg, Div Colorectal Surg
Chung Hwa Univ Med Technol, Dept Med Lab Sci & Biotechnol
Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Chia Nan Univ Pharm & Sci, Dept Pharm
Chi Mei Med Ctr, Dept Radiat Oncol
Chi Mei Med Ctr, Dept Med Res
Southern Taiwan Univ Sci & Technol, Dept Informat Management
Taipei Med Univ, Coll Med, Sch Med, Dept Biochem & Mol Cell Biol
Taipei Med Univ, Coll Med, Grad Inst Med Sci
Taipei Med Univ, Wan Fang Hosp, Cell Physiol & Mol Image Res Ctr |
| 關鍵字: | rectal cancer
neoadjuvant therapy
lymph node yield
quality
survival |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 12:00:34 (UTC+8) |
| 出版者: | DOVE MEDICAL PRESS LTD |
| 摘要: | Purpose: A lymph node (LN) yield >12 is required to for accurate determination of nodal status for colorectal cancer but cannot always be achieved after neoadjuvant therapy. This study aims to determine the difference in LN yield from rectal cancer patients treated with and without neoadjuvant therapy and the effects of specific LN yields on survival. Patients and Methods: The study cohort included a total of 4344 rectal cancer patients treated between January 2007 and December 2015, 2260 (52.03%) of whom received neoadjuvant therapy. Data were retrieved from the Taiwan nationwide cancer registry database. The minimum acceptable LN yield below 12 was investigated using the maximum area under the ROC curve. Results: The median LN yield was 12 (8-17) for patients who received neoadjuvant therapy and 17 (13-24) for those who did not. The recommended LN yield >12 was achieved in 82.73% of patients without and 57.96% of those with neoadjuvant therapy (p < 0.0001). Patients with LN yield >12 had a higher OS probability than did those with LN <12 (OR, 1.33; 95% CI, 1.06-1.66; p = 0.0124). However, the predictive accuracy for survival was greater for LN yield >10 (AUC, 0.7767) than cut-offs of 12, 8, or 6, especially in patients with pathologically-negative nodes (AUC, 0.7660). Conclusion: Neoadjuvant therapy significantly reduces the LN yield in subsequent surgery. A lower yield (LN > 10) may be adequate for nodal evaluation in rectal cancer patients after neoadjuvant therapy. |
| 關聯: | CANCER MANAG RES, v.13, pp.8037-8047 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
[藥學系(所)] 期刊論文
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