Risk of Stroke in Patients with Breast Cancer and Sleep Disorders

doi:10.7150/jca.63184

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/34507

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34507

Title:	Risk of Stroke in Patients with Breast Cancer and Sleep Disorders
Authors:	Chen, Nan-Cheng Liao, Kuang-Ming Tian, Yu-Feng Wu, Yu-Cih Wang, Jhi-Joung Ho, Chung-Han Hsu, Chien-Chin
Contributors:	Chi Mei Med Ctr, Dept Internal Med Southern Taiwan Univ Sci & Technol, Dept Biotechnol & Food Technol Chi Mei Med Ctr, Div Gastroenterol & Gen Surg Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chi Mei Med Ctr, Dept Med Res Chi Mei Med Ctr, Dept Anesthesiol Natl Def Med Ctr, Dept Anesthesiol Southern Taiwan Univ Sci & Technol, Dept Informat Management Taipei Med Univ, Wan Fang Hosp, Canc Ctr Chi Mei Med Ctr, Dept Emergency Med
Keywords:	CARDIOVASCULAR EVENTS TAIWAN
Date:	2021
Issue Date:	2023-11-11 11:59:52 (UTC+8)
Publisher:	IVYSPRING INT PUBL
Abstract:	Breast cancer and stroke were leading cause of cancer-related mortality in the world. Stroke is the second leading cause of death. Previous studies showed that patients with breast cancer had a relatively higher risk of sleep disorders. Sleep disorders increased the risk of stroke. The aim of our study was to examine the risk of stroke after a breast cancer with sleep disorder among women in Taiwan. The Taiwan Cancer Registry was used to identify patients with breast cancer. Patients with new-onset breast cancer from January 2007 to December 2015 were selected for this study and followed until December 31, 2017. Patients who were diagnosed with sleep disorders were set as the case group, and the controls were those without sleep disorders. We enrolled 5256 patients with sleep disorders and 10,512 patients without sleep disorders. There were 121 (2.30%) patients with ischemic stroke among the breast cancer patients with sleep disorders. The mean time from the diagnosis of breast cancer to the occurrence of ischemic stroke was 6.29 +/- 2.59 years for breast cancer patients with sleep disorders and 6.00 +/- 2.76 years for those without sleep disorders (p < 0.0001). After matching by age and index year, breast patients with sleep disorders had a 1.31-fold higher risk (95% confidence interval: 1.03-1.66; p-value=0.026) of ischemic stroke than those without sleep disorders, after adjustment for comorbidities, cancer clinical stage, and treatment types. In conclusion, Breast cancer patients with sleep disorders have an increased risk of stroke.
Relation:	J CANCER, v.12, n.22, pp.6749-6755
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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