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| 標題: | Risk of retinal vein occlusion in patients with diabetes mellitus: A retrospective cohort study |
| 作者: | Chang, Yuh-Shin
Ho, Chung-Han
Chu, Chin-Chen
Wang, Jhi-Joung
Jan, Ren-Long |
| 貢獻者: | Chi Mei Med Ctr, Dept Ophthalmol
Chang Jung Christian Univ, Grad Inst Med Sci, Coll Hlth Sci
Chi Mei Med Ctr, Dept Med Res
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Chi Mei Med Ctr, Dept Anesthesiol
Chia Nan Univ Pharm & Sci, Dept Recreat & Hlth Care Management
Chi Mei Med Ctr, Dept Pediat |
| 關鍵字: | Retinal vein occlusion
Diabetes mellitus
Cohort study
Taiwan National Health Insurance
Research Database |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:59:46 (UTC+8) |
| 出版者: | ELSEVIER IRELAND LTD |
| 摘要: | Aims: To investigate the risk of retinal vein occlusion (RVO) in new-onset diabetes mellitus (DM) patients. Methods: This nationwide, retrospective, matched cohort study included 240,761 DM patients registered between January 2003 and December 2005 in the Longitudinal Cohort of Diabetes Patients database. An age- and sex-matched control group comprising 240,761 non-DM patients (case: control = 1:1) was selected from the Taiwan Longitudinal Health Insurance Database 2000. Information for each patient from the index date until December 2013 was collected. The incidence and risk of RVO were compared between the two groups. Cox proportional hazard regression analysis was performed to calculate the adjusted hazard ratio (HR) for RVO after adjustment for potential confounders. The RVO cumulative incidence rate was obtained using Kaplan-Meier analysis. Results: During the follow-up period, 1,456 DM patients developed RVO (491, central retinal vein occlusion; 965, branch retinal vein occlusion). There was a significantly elevated risk of RVO in DM patients compared with the controls (incidence rate ratio = 1.91, 95% confidence interval [CI] = 1.75-2.08). Patients with DM showed significant risk of RVO after adjustment for potential confounders (hypertension, hyperlipidemia, congestive heart failure, coronary artery disease, and chronic renal disease) in the full cohort (adjusted HR = 1.76, 95% CI = 1. 61-1.93). Additionally, patients with hypertension had a significantly higher risk of RVO than patients without hypertension after adjustment for other confounders in the cohort (adjusted HR = 1.50, 95% CI = 1.36-1.65). Conclusions: We found that patients with DM have increased risks of RVO. In addition to blood pressure control, we recommend educating patients with DM about RVO, to prevent its subsequent occurrence. (C) 2020 Elsevier B.V. All rights reserved. |
| 關聯: | DIABETES RES CLIN PR, v.171, pp.108607 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
[休閒保健管理系(所)] 期刊論文
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