Cedrus atlantica Extract Suppress Glioblastoma Growth through Promotion of Genotoxicity and Apoptosis: In Vitro and In Vivo Studies

doi:10.7150/ijms.54468

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標題:	Cedrus atlantica Extract Suppress Glioblastoma Growth through Promotion of Genotoxicity and Apoptosis: In Vitro and In Vivo Studies
作者:	Chang, Kai-Fu Chang, Jinghua Tsai Huang, Xiao-Fan Huang, Ya-Chih Li, Chia-Yu Weng, Jun-Cheng Hsiao, Chih-Yen Hsu, Hui-Ju Tsai, Nu-Man
貢獻者:	Chung Shan Med Univ, Inst Med Chung Shan Med Univ, Dept Med Lab & Biotechnol Nanhua Univ, Dept Life & Death Chang Gung Univ, Dept Med Imaging & Radiol Sci Ditmanson Med Fdn, Dept Internal Med, Div Nephrol, Chia Yi Christian Hosp Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Chung Shan Med Univ Hosp, Clin Lab
關鍵字:	Glioblastoma Cedrus atlantica DNA damage cell apoptosis drug combination
日期:	2021
上傳時間:	2023-11-11 11:59:43 (UTC+8)
出版者:	IVYSPRING INT PUBL
摘要:	Glioblastoma (GBM) is the most common malignant primary brain tumor in humans, exhibiting highly infiltrative growth and drug resistance to conventional chemotherapy. Cedrus atlantica (CAt) extract has been shown to decrease postoperative pain and inhibit the growth of K562 leukemia cells. The aim of this study was to assess the anti-GBM activity and molecular mechanism of CAt extract in vitro and in vivo. The results showed that CAt extract greatly suppressed GBM cells both in vitro and in vivo and enhanced the survival rate in subcutaneous and orthotopic animal models. Moreover, CAt extract increased the level of ROS and induced DNA damage, resulting in cell cycle arrest at the G(0)/G(1) phase and cell apoptosis. Western blotting results indicated that CAt extract regulates p53/p21 and CDK4/cyclin D1 protein expression and activates extrinsic and intrinsic apoptosis. Furthermore, CAt extract enhanced the cytotoxicity of Temozolomide and decreased AKT/mTOR signaling by combination treatment. In toxicity assays, CAt extract exhibited low cytotoxicity toward normal cells or organs in vitro and in vivo. CAt extract suppresses the growth of GBM by induction of genotoxicity and activation of apoptosis. The results of this study suggest that CAt extract can be developed as a therapeutic agent or adjuvant for GBM treatment in the future.
關聯:	INT J MED SCI, v.18, n.11, pp.2417-2430
顯示於類別:	[醫務管理系(所)] 期刊論文

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