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| 標題: | Postoperative radiotherapy is associated with improved survival in pT1-2N1 oral and oropharyngeal cancer without adequate neck dissection |
| 作者: | Yang, Ching-Chieh
Kang, Bor-Hwang
Liu, Wen-Shan
Yin, Chun-Hao
Lee, Ching-Chih |
| 貢獻者: | Chi Mei Med Ctr, Dept Radiat Oncol
Chia Nan Univ Pharm & Sci, Dept Pharm
Kaohsiung Vet Gen Hosp, Dept Otolaryngol Head & Neck Surg
Natl Def Med Ctr, Sch Med
Tajen Univ, Dept Pharm
Kaohsiung Vet Gen Hosp, Dept Radiaton Oncol
Kaohsiung Vet Gen Hosp, Dept Med Educ & Res
Natl Yang Ming Univ, Inst Hosp & Hlth Care Adm |
| 關鍵字: | Oral cancer
Oropharyngeal cancer
Radiotherapy
Neck dissection
Survival |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:59:33 (UTC+8) |
| 出版者: | BMC |
| 摘要: | Background: To assess the benefit of postoperative radiotherapy in patients with pT1-2N1M0 oral and oropharyngeal cancer by the quality of neck dissection. Methods: In the Surveillance, Epidemiology, and End Results database, pT1-2N1M0 oral and oropharyngeal cancer patients treated by primary tumor resection and neck dissection with or without radiotherapy were included between 2004 and 2015. Univariate and multivariate analysis were used to explore the effect of adjuvant radiotherapy on 5-year overall survival (OS) and disease-specific survival (DSS) among different quality of neck dissection. Results: Of the 1765 patients identified, 1108 (62.8%) had oral cancer, 1141 (64.6%) were men, and 1067 (60.5%) underwent adjuvant radiotherapy. After adjusting for confounding factors, postoperative radiotherapy reduced the adjusted hazard ratio (aHR) of 5-year OS to 0.64 (95% confidence interval [CI] 0.49-0.84) in those with < 18 lymph nodes (LNs) removed, but not in those with 19-24 LNs removed (aHR 0.78; 95% CI 0.73-1.13), and in those with >= 25 LNs removed (aHR 0.96; 95% CI 0.75-1.24). For 5-year DSS, similar effect was observed. The adjusted hazard ratio was 0.66 (95% confidence interval, 0.45-0.97) in those with < 18 LNs. The protective effect was not seen in those with 18-24 LNs (aHR 1.07; 95% CI 0.59-1.96), and in those with >= 25 LNs (aHR 1.12; 95% CI 0.81-1.56). Sensitivity testing also showed a robust protective effect of postoperative radiotherapy in patients with < 18 LNs removed. Conclusion: Radiotherapy was associated with improved survival in pT1-2N1M0 oral and oropharyngeal cancer patients without adequate neck dissection. |
| 關聯: | RADIAT ONCOL, v.16, n.1, pp.6 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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